SIT1 Antibodies

AND SIT1 ELISA kits, SIT1 Proteins

Many biological assays use antibodies to detect SIT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIT1 antibodies...

We validate the specificity of these antibodies to SIT1 by testing them on tissues known to express SIT1 positively and negatively. Browse below to find the SIT1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SIT1 Infographic by Boster Bio

All SIT1 Products

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Product

Figures

Specificity

Applications

Price

Anti-SIT Purified SIT1 Monoclonal Antibody

Human

Flow Cytometry, IP, WB

$315
Cat # M05696
0.1 mg

SIT (SIT1) (NM_014450) Human Recombinant Protein

$813
Cat # PROTQ9Y3P8
20 µg

SIT (SIT1) (NM_014450) Human Over-expression Lysate

Human

$628
Cat # LS027240
100 µg

SIT1 Overview

Facts about Signaling threshold-regulating transmembrane adapter 1.

SIT1 3D structure. Source: alphafold

Signaling threshold-regulating transmembrane adapter 1 (SIT1)

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells.

Gene Information

Human
Gene Name:	SIT1
Uniprot:	Q9Y3P8
Entrez:	27240

Family

Belongs to:

No superfamily

Alternative Names

gp30/40; MGC125908; MGC125909; RP11-331F9.5; SHP2 interacting transmembrane adaptor; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; signaling threshold regulating transmembrane adaptor 1; signaling threshold-regulating transmembrane adapter 1; SIT1; SITMGC125910; suppression inducing transmembrane adaptor 1; Suppression-inducing transmembrane adapter 1

Molecular Weight

Mass (kDA):
21.126 kDA

Genomic Context


Human

Location:	9p13.3
Sequence:	9; NC_000009.12 (35649295..35650931, complement)

Tissue Specificity

Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Tuberculosis
Tuberculosis, Multidrug-resistant
Lung Diseases
Lung Diseases, Obstructive
Malignant Neoplasms
Candidiasis
Chronic Obstructive Airway Disease
Acquired Immunodeficiency Syndrome
Dyslipidemias
Neoplasm Metastasis
Meningeal Disorder
Melanoma
Ataxia

Pellagra
Bronchitis, Chronic
Peripheral Vascular Diseases
Neoplasms
Pulmonary Emphysema
Mycoses
Suppressor Mutation

Pathways

Transport
Virulence
Drug Resistance
Amino Acid Transport
Localization
Coagulation
Amino Acid Homeostasis
Cellular Ion Homeostasis
Chemotaxis
Hemostasis
Dna Methylation
Protein Transport
Proline Transport

Ion Homeostasis
Methylation
Lymphocyte Activation
Cell Activation
Hyphal Growth
T Cell Activation
Fertilization

PTMs

Methylation
Phosphorylation

Glycosylation
Deglycosylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIT1

References

PMID: 10209036 by Marie-Cardine A., et al. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T-cell activation.

PMID: 11491537 by Huebener C., et al. Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT).