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- Table of Contents
Facts about Chromodomain-helicase-DNA-binding protein 5.
Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 in'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages.
Human | |
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Gene Name: | CHD5 |
Uniprot: | Q8TDI0 |
Entrez: | 26038 |
Belongs to: |
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SNF2/RAD54 helicase family |
ATP-dependent helicase CHD5; CHD-5; chromodomain helicase DNA binding protein 5; chromodomain-helicase-DNA-binding protein 5; DKFZp434N231; EC 3.6.1; EC 3.6.4.12; KIAA0444
Mass (kDA):
223.05 kDA
Human | |
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Location: | 1p36.31 |
Sequence: | 1; NC_000001.11 (6101787..6180321, complement) |
Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis.
Nucleus. Associates with heterochromatin.
PMID: 12592387 by Thompson P.M., et al. CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system.
PMID: 17289567 by Bagchi A., et al. CHD5 is a tumor suppressor at human 1p36.