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SIGMAR1 Antibodies
AND SIGMAR1 ELISA kits, SIGMAR1 Proteins
Many biological assays use antibodies to detect SIGMAR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIGMAR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIGMAR1 antibodies...
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SIGMAR1 Infographic by Boster Bio
All SIGMAR1 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A02493-2
100 μg/vial
Cat # A02493-2
100 μg/vial
SIGMAR1 Overview
Facts about Sigma non-opioid intracellular receptor 1.
Sigma non-opioid intracellular receptor 1 (SIGMAR1)
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide selection of cellular functions probably through regulation of the biogenesis of lipid microdomains in the plasma membrane. Involved in the regulation of distinct receptors it plays a role in BDNF signaling and EGF signaling.
Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux in the endoplasmic reticulum.
Gene Information
| Human | |
|---|---|
| Gene Name: | SIGMAR1 |
| Uniprot: | Q99720 |
| Entrez: | 10280 |
Family
| Belongs to: |
|---|
| ERG2 family |
Alternative Names
Aging-associated gene 8 protein; ALS16; FLJ25585; hSigmaR1; OPRS1; SIG-1R; sigma 1; Sigma 1-type opioid receptor; sigma non-opioid intracellular receptor 1; Sigma-1 R; sigma1 receptor; Sigma1R; Sigma-1R; sigma1-receptor; SIGMAR1; SR31747 binding protein 1; SR31747-binding protein; SRBP; SR-BP; SR-BP1; SRBPMGC3851; type I sigma receptor
Molecular Weight
Mass (kDA):
25.128 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.3 |
| Sequence: | 9; NC_000009.12 (34634722..34637826, complement) |
Tissue Specificity
Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020).
Subcellular Localizations
Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Cell junction, synapse, postsynaptic density membrane. During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (PubMed:10406945). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic ret
Diseases
- Neurodegenerative Disorders
- Schizophrenia
- Alzheimer's Disease
- Sclerosis
- Primary Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
- Retinal Diseases
- Nerve Degeneration
- Retinal Degeneration
- Dementia
- Motor Neuron Disease
- Dysequilibrium Syndrome
- Diabetic Retinopathy
Interacting Proteins
- DRD2
Pathways
- Pathogenesis
- Neuroprotection
- Cell Death
- Cell Growth
- Rna Interference
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIGMAR1
bosterbio.com/bosterbio-gene-info-cards/SIGMAR1
References
PMID: 8954936 by Kekuda R., et al. Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).
PMID: 9341151 by Jbilo O., et al. Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase.