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- Table of Contents
Facts about Sialic acid-binding Ig-like lectin 5.
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. .
Human | |
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Gene Name: | SIGLEC5 |
Uniprot: | O15389 |
Entrez: | 8778 |
Belongs to: |
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immunoglobulin superfamily |
Siglec-5/Siglec-14
Mass (kDA):
60.715 kDA
Human | |
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Location: | 19q13.41 |
Sequence: | 19; NC_000019.10 (51610967..51630474, complement) |
Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
Membrane; Single-pass type I membrane protein.
PMID: 9731071 by Cornish A.L., et al. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.
PMID: 10428856 by Patel N., et al. OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily.