Serine/threonine-protein kinase RIO3 (RIOK3)

Involved in regulation of type I interferon (IFN)- dependent immune response which plays a vital role in the innate immune response against DNA and RNA viruses. May act as an adapter protein critical for the recruitment of TBK1 to IRF3 (PubMed:24807708).

Phosphorylates IFIH1 on'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of this NF-kappaB signaling pathway (PubMed:19557502).