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- Table of Contents
Facts about Serine/threonine-protein kinase RIO3.
Phosphorylates IFIH1 on'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of this NF-kappaB signaling pathway (PubMed:19557502).
Human | |
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Gene Name: | RIOK3 |
Uniprot: | O14730 |
Entrez: | 8780 |
Belongs to: |
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protein kinase superfamily |
DKFZp779L1370; EC 2.7.11.1; homolog of the Aspergillus nidulans sudD gene product; RIO kinase 3 (yeast); RIO kinase 3; serine/threonine-protein kinase RIO3; sudD (suppressor of bimD6, Aspergillus nidulans) homolog; sudD homolog; sudD suppressor of bimD6 homolog; SUDDsudD suppressor of Aspergillus nidulans bimD6 homolog
Mass (kDA):
59.093 kDA
Human | |
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Location: | 18q11.2 |
Sequence: | 18; NC_000018.10 (23452823..23483140) |
Widely expressed.
Cytoplasm.
PMID: 9602165 by Anaya P., et al. Isolation of the Aspergillus nidulans sudD gene and its human homologue.
PMID: 19557502 by Shan J., et al. RIOK3 interacts with caspase-10 and negatively regulates the NF- kappaB signaling pathway.