SID1 transmembrane family member 2 (SIDT2)

Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a procedure in which RNA or DNA is directly imported into lysosomes in an ATP- dependent fashion, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980).

Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA better than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA.