Shootin-1 Antibodies

AND SHTN1 ELISA kits, Shootin-1 Proteins

Many biological assays use antibodies to detect Shootin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Shootin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Shootin-1 antibodies...

We validate the specificity of these antibodies to Shootin-1 by testing them on tissues known to express SHTN1 positively and negatively. Browse below to find the SHTN1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: FAM160B1

SHTN1 Infographic by Boster Bio

All SHTN1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

SHTN1 (NM_018330) Human Recombinant Protein

$1062
Cat # PROTA0MZ66
20 µg

SHTN1 Overview

Facts about Shootin-1.

SHTN1 3D structure. Source: alphafold

Shootin-1 (SHTN1)

Involved in the creation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium expansion and axon outgrowth.

Plays a role in cytoskeletal organization by controlling the subcellular localization of phosphoinositide 3-kinase (PI3K) activity in the axonal growth cone. Plays also a role in regenerative neurite outgrowth.

Gene Information

Human
Gene Name:	SHTN1
Uniprot:	A0MZ66
Entrez:	57698

Family

Belongs to:

shootin family

Alternative Names

Shootin-1

Molecular Weight

Mass (kDA):
71.64 kDA

Genomic Context


Human

Location:	10q25.3
Sequence:	10; NC_000010.11 (116881477..117126586, complement)

Subcellular Localizations

Perikaryon. Cell projection, axon. Cell projection, growth cone. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, lamellipodium. Localizes in multiple growth cones at neurite tips before the neuronal symmetry-breaking step. Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step; when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons. Transported anterogradely from the soma to the axon growth cone in an actin and myosin-depende

Interacting Proteins

BBOX1
ESRRG
FABP3
NME7
TFCP2

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHTN1

References

PMID: 17030985 by Toriyama M., et al. Shootin1: a protein involved in the organization of an asymmetric signal for neuronal polarization.