Endophilin-A1 Antibodies

AND SH3GL2 ELISA kits, Endophilin-A1 Proteins

Many biological assays use antibodies to detect Endophilin-A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Endophilin-A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Endophilin-A1 antibodies...

We validate the specificity of these antibodies to Endophilin-A1 by testing them on tissues known to express SH3GL2 positively and negatively. Browse below to find the SH3GL2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SH3GL2 Infographic by Boster Bio

All SH3GL2 Products

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Product

Figures

Specificity

Applications

Price

Anti-Endophilin I SH3GL2 Antibody

Human, Mouse

IF, WB

$405
Cat # A05430
100ul

Anti-Endophilin I (P84) SH3GL2 Antibody

Mouse, Rat

$405
Cat # A05430-1
100ul

SH3GL2 (NM_003026) Human Recombinant Protein

$1062
Cat # PROTQ99962
20 µg

Anti-SH3GL2 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A05430-2
100 μg/vial

Anti-SH3GL2 Antibody Picoband® (monoclonal, 6I8E1)

Mouse, Rat

$370
Cat # M05430
100 μg/vial

SH3GL2 (NM_003026) Human Over-expression Lysate

Human

$628
Cat # LS006456
100 µg

SH3GL2 Overview

Facts about Endophilin-A1.

SH3GL2 3D structure. Source: alphafold

Endophilin-A1 (SH3GL2)

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.

Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.

Gene Information

Human
Gene Name:	SH3GL2
Uniprot:	Q99962
Entrez:	6456

Family

Belongs to:

endophilin family

Alternative Names

CNSA2; CNSA2FLJ25015; EEN-B1; EEN-B1bA335L15.1 (SH3-domain GRB2-like 2); Endophilin A1; Endophilin-1; endophilin-A1; FLJ20276; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3D2A; SH3D2AEndophilin A1 BAR domain; SH3-domain GRB2-like 2; SH3GL2; SH3P4; SH3P4endophilin-1

Molecular Weight

Mass (kDA):
39.962 kDA

Genomic Context


Human

Location:	9p22.2
Sequence:	9; NC_000009.12 (17579066..17797124)

Tissue Specificity

Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Cell junction, synapse, presynapse.

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Neurodegenerative Disorders
Malignant Squamous Cell Neoplasm
Neoplasm Metastasis
Laryngeal Neoplasm
Carcinogenesis
Laryngeal Squamous Cell Carcinoma
Ataxia
Dysplasia
Epilepsy

Ataxia, Spinocerebellar
Malignant Neoplasm Of Larynx
Nervousness
Atrial Premature Complexes
Cell Invasion
Cell Transformation, Neoplastic
Spinocerebellar Ataxia Type 2

Interacting Proteins

ADAM15
ADAM9
ATXN2
DNM2
EMD

LRRK2
PTPN23
RAPH1
SH3GL1
SH3GL3

SH3KBP1
Synj1

Pathways

Endocytosis
Clathrin-mediated Endocytosis
Synaptic Vesicle Endocytosis
Membrane Fission
Transport
Cell Cycle
Localization
Methylation
Cell Death
Pathogenesis
Cell Motility
Vesicle Uncoating
Receptor Internalization

Membrane Invagination
Cell Adhesion
Synaptic Vesicle Uncoating
Fertilization
Regulation Of Cytoskeleton
Synaptic Vesicle Retrieval
Proteolysis

PTMs

Phosphorylation
Methylation

Ubiquitination
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH3GL2

References

PMID: 9169142 by Giachino C., et al. A novel SH3-containing human gene family preferentially expressed in the central nervous system.

PMID: 10531379 by Howard L., et al. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.