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SH2D2A Antibodies
AND SH2D2A ELISA kits, SH2D2A Proteins
Many biological assays use antibodies to detect SH2D2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH2D2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH2D2A antibodies...
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SH2D2A Infographic by Boster Bio
All SH2D2A Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M06232
100 µl
Cat # M06232
100 µl
Human, Monkey, Mouse
Flow Cytometry, IF, IHC, WB
$523
Cat # M06232-1
100 µl
Cat # M06232-1
100 µl
SH2D2A Overview
Facts about SH2 domain-containing protein 2A.
SH2 domain-containing protein 2A (SH2D2A)
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway.
Could also play an essential role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | SH2D2A |
| Uniprot: | Q9NP31 |
| Entrez: | 9047 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
F2771; RIBP; SCAP; SH2 domain containing 2A; SH2 domain protein 2A; SH2 domain-containing adapter protein; SH2D2A; T cell specific adapter protein TSAd; T cell-specific adapter protein; T lymphocyte specific adaptor protein; TSAd; TSADSH2 domain-containing protein 2A; VEGF receptor-associated protein; VRAP
Molecular Weight
Mass (kDA):
42.934 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.1 |
| Sequence: | 1; NC_000001.11 (156806238..156816853, complement) |
Tissue Specificity
Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.
Subcellular Localizations
Cytoplasm.
Diseases
- Autoimmune Reaction
- Sclerosis
- Autoimmune Diseases
- Multiple Sclerosis
- Autoimmunity
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
- Neoplasms
- Lymphoma
- Polyradiculoneuropathy
- Infective Disorder
- Tissue Adhesions
- Lymphoproliferative Disorders
- Polyneuropathy
Interacting Proteins
- AR
- ASB3
- DCAF12L1
- ERBB2
- GAB1
- KIT
- LASP1
- LCK
- MET
- PIK3R3
Pathways
- Cell Activation
- T Cell Activation
- Cell Death
- Cell Development
- Cell Migration
- Hypersensitivity
- Cell Differentiation
- Cell Proliferation
- T Cell Migration
- T Cell Differentiation
- Pathogenesis
- Secretion
- Cell Adhesion
PTMs
- Phosphorylation
Research Areas
- Angiogenesis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH2D2A
bosterbio.com/bosterbio-gene-info-cards/SH2D2A
References
PMID: 9468509 by Spurkland A., et al. Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites.
PMID: 10752626 by Dai K.Z., et al. The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.