SH2D1B Antibodies

AND SH2D1B ELISA kits, SH2D1B Proteins

Many biological assays use antibodies to detect SH2D1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH2D1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH2D1B antibodies...

We validate the specificity of these antibodies to SH2D1B by testing them on tissues known to express SH2D1B positively and negatively. Browse below to find the SH2D1B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SH2D1B Infographic by Boster Bio

All SH2D1B Products

Product

Figures

Specificity

Applications

Price

Anti-EAT-2 SH2D1B Antibody

Human

ELISA, IHC

$380
Cat # A08391
100ul

Human SH2D1B Recombinant Protein

SDS-PAGE

$250
Cat # PROTO14796
Starting from 10ug

SH2D1B (NM_053282) Human Over-expression Lysate

Human

$628
Cat # LS117157
100 µg

SH2D1B Overview

Facts about SH2 domain-containing protein 1B.

SH2D1B 3D structure. Source: alphafold

SH2 domain-containing protein 1B (SH2D1B)

Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling appears to collaborate with SH2D1A/SAP.

Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity).

Gene Information

Human
Gene Name:	SH2D1B
Uniprot:	O14796
Entrez:	117157

Family

Belongs to:

No superfamily

Alternative Names

EAT2EAT-2; EWS/FLI1-activated transcript 2; SH2 domain containing 1B; SH2 domain-containing molecule EAT2; SH2 domain-containing protein 1B

Molecular Weight

Mass (kDA):
15.297 kDA

Genomic Context


Human

Location:	1q23.3
Sequence:	1; NC_000001.11 (162395268..162412136, complement)

Diseases

X-linked Lymphoproliferative Disorders
Lymphoproliferative Disorders
Neoplasms
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Sarcoma
Immunologic Deficiency Syndromes
Virus Diseases
Cell Transformation, Neoplastic
Epstein-barr Virus Infections
Infective Disorder
Agammaglobulinemia
Right-sided Displacement Of Abomasum

T(11;22)(q24;q12)
B-cell Lymphomas
Bone Neoplasms
Respiratory Tract Infections
Foot-and-mouth Disease
Acute Infectious Disease
Neuroectodermal Tumors

Interacting Proteins

AR
CD244
CD84
GAB1
KIT

MET
OLIG1
PLCG1
PLCG2
SLAMF6

TRIM54

Pathways

Lymphocyte Activation
Cell Activation
Oncogenesis
Cytokine Production
T Cell Activation
Immune Response

PTMs

Phosphorylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH2D1B

References

PMID: 11689425 by Morra M., et al. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.

PMID: 12115647 by Tangye S.G., et al. CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2.