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GNE Antibodies
AND GNE ELISA kits, GNE Proteins
Many biological assays use antibodies to detect GNE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GNE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GNE antibodies...
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GNE Overview
Facts about Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE)
Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an important role in early development (By similarity).
Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | GNE |
| Uniprot: | Q9Y223 |
| Entrez: | 10020 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; GLCNENM; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; GNE; IBM2; NAcetylmannosamine Kinase; N-Acetylmannosamine Kinase; N-acylmannosamine kinase; Uae1; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
Molecular Weight
Mass (kDA):
79.275 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.3 |
| Sequence: | 9; NC_000009.12 (36214441..36277056, complement) |
Tissue Specificity
Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas. Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon.
Subcellular Localizations
Cytoplasm.
Diseases
- Myopathy
- Distal Muscular Dystrophies
- Inclusion Body Myositis (disorder)
- Weakness
- Muscle Weakness
- Muscular Dystrophy
- Atrophy
- Neuromuscular Diseases
- Sialuria
- Tissue Adhesions
- Muscular Atrophy
- Dystrophy
- Inflammation
Interacting Proteins
- ACTN1
- GTPBP3
- KRT31
- KRTAP10-5
- KRTAP10-7
- KRTAP10-8
- KRTAP10-9
- KRTAP4-12
- KRTAP5-9
- KRTAP9-2
Pathways
- Pathogenesis
- Cell Adhesion
- Glycosylation
- Regeneration
- Muscle Atrophy
- Localization
- Virulence
- Autophagy
- Protein Glycosylation
- Cell Proliferation
- Anoikis
- Cell Growth
- Rna Interference
PTMs
- Phosphorylation
- Glycosylation
- Demethylation
- Nitrosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GNE
bosterbio.com/bosterbio-gene-info-cards/GNE
References
PMID: 10431835 by Lucka L., et al. Primary structure and expression analysis of human UDP-N-acetyl- glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis.
PMID: 10330343 by Seppala R., et al. Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme.