SH2B adapter protein 2 Antibodies

AND SH2B2 ELISA kits, SH2B adapter protein 2 Proteins

Many biological assays use antibodies to detect SH2B adapter protein 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH2B adapter protein 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH2B adapter protein 2 antibodies...

We validate the specificity of these antibodies to SH2B adapter protein 2 by testing them on tissues known to express SH2B2 positively and negatively. Browse below to find the SH2B2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SH2B2 Infographic by Boster Bio

All SH2B2 Products

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Anti-APS SH2B2 Antibody

3 Q&As

Human, Mouse, Rat

$399
Cat # A09167
100μl

SH2B2 (NM_020979) Human Recombinant Protein

$1249
Cat # PROTO14492
20 µg

SH2B2 Overview

Facts about SH2B adapter protein 2.

SH2B2 3D structure. Source: alphafold

SH2B adapter protein 2 (SH2B2)

Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways.

May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in cooperation with CBL.

Gene Information

Human
Gene Name:	SH2B2
Uniprot:	O14492
Entrez:	10603

Family

Belongs to:

SH2B adapter family

Alternative Names

adaptor protein with pleckstrin homology and src homology 2 domains; APSAdapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2; SH2B adaptor protein 2

Molecular Weight

Mass (kDA):
67.738 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (102284525..102321711)

Tissue Specificity

Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines.

Subcellular Localizations

Cytoplasm. Cell membrane. Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.

Diseases

Polyendocrinopathies, Autoimmune
Tissue Adhesions
Janiceps
Malignant Neoplasms
Cardiovascular Diseases
Myeloproliferative Disease
Autoimmune Reaction
Burkitt Lymphoma
Colonic Neoplasms
Malignant Tumor Of Colon
Pre-eclampsia
Leukemia, Myelocytic, Acute
Osteosarcoma

Neoplasms
Nervousness
Lymphoma
Antiphospholipid Syndrome
Ovarian Neoplasm
Celiac Disease
Primary Myelofibrosis

Interacting Proteins

Pathways

Cell Proliferation
Cell Adhesion
Cell Growth
Actin Cytoskeleton Organization
Cell Activation
Induction Of Apoptosis
Cell Development
T Cell Activation
Aging
B Cell Proliferation
Localization
Nuclear Export
Glucose Homeostasis

Regeneration
Cytoskeleton Organization
Mrna Splicing
Cell Cycle
Pathogenesis
Lymphocyte Differentiation
Nuclear Import

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH2B2

References

PMID: 9233773 by Yokouchi M., et al. Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.

PMID: 10374881 by Wakioka T., et al. APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.