SGSM2 Antibodies

AND SGSM2 ELISA kits, SGSM2 Proteins

Many biological assays use antibodies to detect SGSM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SGSM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SGSM2 antibodies...

We validate the specificity of these antibodies to SGSM2 by testing them on tissues known to express SGSM2 positively and negatively. Browse below to find the SGSM2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SGSM2 Infographic by Boster Bio

All SGSM2 Products

Product

Figures

Specificity

Applications

Price

Anti-SGSM2 Antibody

Human, Mouse, Rat

ELISA, IF, WB

$449
Cat # A12146
0.1 mg

SGSM2 (NM_001098509) Human Over-expression Lysate

Human

$960
Cat # LS009905
100 µg

SGSM2 Overview

Facts about Small G protein signaling modulator 2.

SGSM2 3D structure. Source: alphafold

Small G protein signaling modulator 2 (SGSM2)

Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068).
Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38.

Inhibits RAB32 and RAB38 activation both directly by boosting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction that's needed for RAB32/38 activation (PubMed:26620560). .

Gene Information

Human
Gene Name:	SGSM2
Uniprot:	O43147
Entrez:	9905

Family

Belongs to:

RUTBC family

Alternative Names

KIAA0397; RUN and TBC1 domain containing 1; RUN and TBC1 domain-containing protein 1; RUTBC1; small G protein signaling modulator 2 protein; small G protein signaling modulator 2

Molecular Weight

Mass (kDA):
113.285 kDA

Genomic Context


Human

Location:	17p13.3
Sequence:	17; NC_000017.11 (2336492..2381074)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm. Melanosome. Melanosomal localization is mediated by RAB9A.

Diseases

Insulin Resistance
Diabetes Mellitus, Non-insulin-dependent
Coronary Heart Disease
Obesity
Nervousness
Coronary Artery Disease

Diabetes Mellitus

Pathways

Transport
Glucose Homeostasis
Neuronal Signal Transduction
Insulin Processing
Pathogenesis

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SGSM2

References

PMID: 17509819 by Yang H., et al. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.

PMID: 21808068 by Nottingham R.M., et al. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.