Shugoshin 2 Antibodies

AND SGO2 ELISA kits, Shugoshin 2 Proteins

Many biological assays use antibodies to detect Shugoshin 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Shugoshin 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Shugoshin 2 antibodies...

We validate the specificity of these antibodies to Shugoshin 2 by testing them on tissues known to express SGO2 positively and negatively. Browse below to find the SGO2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SGO2 Infographic by Boster Bio

All SGO2 Products

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Anti-SGOL2 SGO2 Antibody

1 Q&As

Human, Mouse, Rat

ELISA, IHC-P, IF (paraffin)

$335
Cat # A30763
100ul

Anti-SGOL2 Antibody (Center)

Human

$299
Cat # A30763-1
80 µl

Anti-SGO2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A08632
100 μg/vial

SGO2 Overview

Facts about Shugoshin 2.

SGO2 3D structure. Source: alphafold

Shugoshin 2 (SGO2)

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes especially during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase.

During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus vital for an accurate gametogenesis.

Gene Information

Human
Gene Name:	SGO2
Uniprot:	Q562F6
Entrez:	151246

Family

Belongs to:

shugoshin family

Alternative Names

Shugoshin 2

Molecular Weight

Mass (kDA):
144.739 kDA

Genomic Context


Human

Location:	2q33.1
Sequence:	2; NC_000002.12 (200510198..200584096)

Subcellular Localizations

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at

Interacting Proteins

CDCA8
MAD2L1
MAD2L1BP
PPP1CA

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SGO2

References

PMID: 16541025 by Kitajima T.S., et al. Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PMID: 17485487 by Huang H., et al. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments.