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SGK1 Antibodies
AND SGK1 ELISA kits, SGK1 Proteins
Many biological assays use antibodies to detect SGK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SGK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SGK1 antibodies...
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SGK1 Infographic by Boster Bio
All SGK1 Products
Product
Figures
Specificity
Applications
Price
Anti-SGK1/Sgk Rabbit Monoclonal Antibody
1 Citations 17 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$370
Cat # M00673
100 μl
Cat # M00673
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1518
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1518
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2001
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2001
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2178
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2178
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00673
100 μg/vial
Cat # A00673
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00673-2
100 μg/vial
Cat # A00673-2
100 μg/vial
SGK1 Overview
Facts about Serine/threonine-protein kinase Sgk1.
Serine/threonine-protein kinase Sgk1 (SGK1)
Serine/threonine-protein kinase that is involved in the regulation of a wide array of ion channels, membrane transporters, mobile enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an essential role in cellular stress response.
Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Stimulates sodium transfer into epithelial cells by improving the stability and expression of SCNN1A/ENAC.
Gene Information
| Human | |
|---|---|
| Gene Name: | SGK1 |
| Uniprot: | O00141 |
| Entrez: | 6446 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; serum/glucocorticoid regulated kinase; Serum/glucocorticoid-regulated kinase 1; SGK; SGK1
Molecular Weight
Mass (kDA):
48.942 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q23.2 |
| Sequence: | 6; NC_000006.12 (134169246..134318112, complement) |
Tissue Specificity
Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregul
Diseases
- Hypertensive Disease
- Neoplasms
- Malignant Neoplasms
- Kidney Diseases
- Fibrosis
- Diabetes Mellitus
- Inflammation
- Diabetic Nephropathy
- Proteinuria Of Undiagnosed Cause
- Ischemia
- Diabetes Mellitus, Non-insulin-dependent
- Edema
- Hypernatremia
Interacting Proteins
- TSC2
- Wnk4
Pathways
- Transport
- Excretion
- Secretion
- Localization
- Cell Proliferation
- Ion Transport
- Pathogenesis
- Cell Growth
- Glucose Transport
- Cell Death
- Cell Cycle
- Gastric Acid Secretion
- Acid Secretion
PTMs
- Phosphorylation
- Ubiquitination
- Dephosphorylation
- Methylation
- Cleavage
Research Areas
- Apoptosis
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SGK1
bosterbio.com/bosterbio-gene-info-cards/SGK1
References
PMID: 9114008 by Waldegger S., et al. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.
PMID: 9722955 by Waldegger S., et al. Genomic organization and chromosomal localization of the human SGK protein kinase gene.
3 Publications of Boster SGK1 Antibodies & ELISA Kits
- PubMed ID: 33063281, Liu BW,Zhang J,Hong YS,Li NB,Liu Y,Zhang M,Wu WY,Zheng H,Lampert A,Zhang XW.NGF-...
- PubMed ID: 27701413, Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours...
- PubMed ID: 29212953, Scortegagna M1, Berthon A2, Settas N2, Giannakou A2, Garcia G1, Li JL1, James B1...
*More publications can be found for each product on its corresponding product page