SCG5 Antibodies

AND SCG5 ELISA kits, SCG5 Proteins

Many biological assays use antibodies to detect SCG5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCG5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCG5 antibodies...

We validate the specificity of these antibodies to SCG5 by testing them on tissues known to express SCG5 positively and negatively. Browse below to find the SCG5 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SCG5 Infographic by Boster Bio

All SCG5 Products

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Product

Figures

Specificity

Applications

Price

Anti-7B2 SCG5 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A06704
100ul

Human SCG5 Recombinant Protein

SDS-PAGE

$250
Cat # PROTP05408
Starting from 10ug

Secretogranin V (SCG5) (NM_003020) Human Over-expression Lysate

Human

$628
Cat # LS006447
100 µg

SCG5 Overview

Facts about Neuroendocrine protein 7B2.

SCG5 3D structure. Source: alphafold

Neuroendocrine protein 7B2 (SCG5)

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated.

Also necessary for cleavage of PCSK2 but doesn't seem to be involved in its folding. Plays a role in regulating pituitary hormone secretion.

Gene Information

Human
Gene Name:	SCG5
Uniprot:	P05408
Entrez:	6447

Family

Belongs to:

7B2 family

Alternative Names

neuroendocrine protein 1 (7B2 protein); Pituitary polypeptide; prohormone convertase chaperone; secretogranin V (7B2 protein); Secretogranin V; secretogranin-5; Secretory granule endocrine protein I

Molecular Weight

Mass (kDA):
23.73 kDA

Genomic Context


Human

Location:	15q13.3
Sequence:	15; NC_000015.10 (32641613..32697098)

Subcellular Localizations

Secreted. Neuroendocrine and endocrine secretory granules.

Diseases

Pituitary Diseases
Neoplasms
Adenoma
Carcinoma
Pituitary Neoplasms
Insulinoma
Pancreatic Neoplasm
Malignant Neoplasms
Carcinoid Tumor
Nervousness
Pituitary Adenoma
Prader-willi Syndrome
Acromegaly

Pheochromocytoma
Medullary Carcinoma Of Thyroid
Glucagonoma
Malignant Paraganglionic Neoplasm
Hypothyroidism
Diabetes Mellitus
Lung Neoplasms

Interacting Proteins

UBQLN1

Pathways

Secretion
Localization
Secretory Pathway
Regulated Secretory Pathway
Transport
Pigmentation
Glucose Homeostasis
Cell Proliferation
Methylation
Cellular Localization
Pathogenesis
Aging
Zymogen Activation

Proteolysis
Regulation Of Secretion
Transcytosis
Flight
Translation
Cell Cycle
Cell Differentiation

PTMs

Cleavage
Methylation

Demethylation
Phosphorylation

Glycosylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCG5

References

PMID: 3134253 by Martens G.J.M.; Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2.

PMID: 1989596 by Paquet L., et al. The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man.