SF3B2 Antibodies

AND SF3B2 ELISA kits, SF3B2 Proteins

Many biological assays use antibodies to detect SF3B2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SF3B2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SF3B2 antibodies...

We validate the specificity of these antibodies to SF3B2 by testing them on tissues known to express SF3B2 positively and negatively. Browse below to find the SF3B2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: ILVBL

SF3B2 Infographic by Boster Bio

All SF3B2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Splicing factor 3B subunit 2 SF3B2 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A07047
100ul

SF3B2 (NM_006842) Human Over-expression Lysate

Human

$960
Cat # LS010992
100 µg

Anti-SF3B2 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A07047-1
100 μg/vial

SF3B2 Overview

Facts about Splicing factor 3B subunit 2.

SF3B2 3D structure. Source: alphafold

Splicing factor 3B subunit 2 (SF3B2)

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complicated (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.

Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114).

Gene Information

Human
Gene Name:	SF3B2
Uniprot:	Q13435
Entrez:	10992

Family

Belongs to:

No superfamily

Alternative Names

Cus1; pre-mRNA splicing factor SF3b 145 kDa subunit; Pre-mRNA-splicing factor SF3b 145 kDa subunit; SAP145SAP 145; SF3b1; SF3B145; SF3b150; spliceosome associated protein 145; Spliceosome-associated protein 145; splicing factor 3B subunit 2; splicing factor 3b, subunit 2, 145kD; splicing factor 3b, subunit 2, 145kDa

Molecular Weight

Mass (kDA):
100.228 kDA

Genomic Context


Human

Location:	11q13.1
Sequence:	11; NC_000011.10 (66052361..66069308)

Subcellular Localizations

Nucleus. Nucleus speckle.

Diseases

Immunologic Deficiency Syndromes
Malignant Neoplasms
Neoplasms
Hiv Infections
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm
Spinocerebellar Ataxia Type 5
Neurodegenerative Disorders
Malignant Neoplasm Of Breast
Uterine Cervical Neoplasm
Ataxia
Malignant Tumor Of Cervix

Carcinoma
Head And Neck Neoplasms
Steroid Sulfatase Deficiency Disease
Cytogenetic Abnormality
Hyperplasia
Ataxia, Spinocerebellar
Esophageal Neoplasms

Interacting Proteins

DHX16
FRA10AC1
KDM1A
PRPF3
PRPF8

RNF113A
SF3B4
SLU7
U2AF1
XAB2

ZNF830

Pathways

Cell Cycle
Translation
Cell Cycle Arrest
Ribosome Biogenesis
G2 Phase
Localization
Nuclear Import

Oncogenesis

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SF3B2

References

PMID: 8566756 by Gozani O., et al. Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A.

PMID: 10882114 by Das R., et al. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E.