Splicing factor 1 Antibodies

Splicing factor 1 (SF1)

Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of this pre-mRNA.

May act as transcription repressor. .

Gene Information

Human
Gene Name:	SF1
Uniprot:	Q15637
Entrez:	7536

Family

Belongs to:
BBP/SF1 family

Alternative Names

Mammalian branch point-binding protein; mBBP; splicing factor 1; Transcription factor ZFM1; ZFM1BBP; Zinc finger gene in MEN1 locus; Zinc finger protein 162D11S636; ZNF162MBBP

Molecular Weight

Mass (kDA):
68.33 kDA

Genomic Context

Human
Location:	11q13.1
Sequence:	11; NC_000011.10 (64764604..64778844, complement)

Tissue Specificity

Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.

Subcellular Localizations

Nucleus.

Diseases

• Neoplasms
• Disorders Of Sex Development
• Congenital Abnormality
• Hypoplasia
• Pituitary Diseases
• Adrenal Gland Hypofunction
• Gonadal Dysgenesis
• Congenital Absence Of Adrenal Gland
• Congenital Hypoplasia Of Adrenal Gland
• Hypogonadism
• Malignant Neoplasms
• Hypogonadotropic Hypogonadism
• Carcinoma

• Nephroblastoma
• 46, Xy Disorders Of Sex Development
• Virilism
• Haploinsufficiency
• Xx Male
• Hyperplasia
• Tumors Of Adrenal Cortex

Interacting Proteins

• ABL2
• CEP104
• Cep104
• CHERP
• Cherp

• CIAO1
• Cltc
• DDX17
• DDX5
• FAM168A

• HNRNPAB
• HNRNPDL
• KHDC4
• Khdc4
• KPNA1

• Kpna1
• KPNA2
• Kpna2
• Kpna4
• KPNA6

• KRTAP26-1
• MKRN3
• PRMT2
• PRPF40A
• PSMA3

• RBM17
• SF3A1
• SF3A2
• SFSWAP
• Sfswap

• TRIM69
• U2AF2
• U2af2
• UHMK1

Pathways

• Sex Determination
• Sex Differentiation
• Localization
• Cell Differentiation
• Gonad Development
• Secretion
• Transport
• Sertoli Cell Differentiation
• Translation
• Cell Proliferation
• Cell Cycle
• Spermatogenesis
• Energy Homeostasis

• Fertilization
• Male Sex Determination
• Cell Migration
• Virulence
• Rna Splicing
• Cell Death
• Dna Repair

PTMs

• Cleavage
• Phosphorylation
• Hydroxylation
• Oxidation

• Methylation
• Nitration
• Glycosylation
• Deacetylation

• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SF1

Boster Bio - Best Uses Of The SF1 Marker

Optimizing experiments is an integral part of the research process, and Boster Bio has several optimization guides available to help you achieve maximum results. The following guide will answer common questions and provide useful guidelines to optimize experiments and obtain better results. No researcher is immune from trouble with experiments. Fortunately, there are many possible sources of error that can be eliminated with the help of proper controls. In addition to optimizing your experiments, this guide will help you troubleshoot common problems.

Super Vision Detection kits

The primary-secondary-ABC system for protein detection is a powerful tool used to detect proteins. The system features avidins conjugated with signal molecules, most commonly Horseradish Peroxide (HRP), which enables researchers to pinpoint proteins of interest. This method is highly specific, with low background. Several other detection systems have been developed, including those that use polysaccharides or organic polymers. Super Vision Detection kits are one example of such innovative technology.

Optimization guides

If you're looking to optimize your IHC experiments, use the Boster Bio optimization guides to get the best results. Boster Bio's guides cover all the aspects of the immunohistochemistry process, from sample preparation to the final results. In addition to providing the best possible results, these guides also help you troubleshoot and answer common questions. These guides also address common issues such as high background or weak staining.