Actin-histidine N-methyltransferase (Setd3)

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me) (PubMed:21832073). Acts as a transcriptional activator (PubMed:21832073).

Plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1 (PubMed:21832073). .