Sestrin-2 Antibodies

AND SESN2 ELISA kits, Sestrin-2 Proteins

Many biological assays use antibodies to detect Sestrin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sestrin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sestrin-2 antibodies...

We validate the specificity of these antibodies to Sestrin-2 by testing them on tissues known to express SESN2 positively and negatively. Browse below to find the SESN2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SESN2 Infographic by Boster Bio

All SESN2 Products

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Figures

Specificity

Applications

Price

Anti-SESTRIN2 SESN2 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A02558
0.1 mg

SESN2 (NM_031459) Human Over-expression Lysate

Human

$628
Cat # LS083667
100 µg

SESN2 Overview

Facts about Sestrin-2.

SESN2 3D structure. Source: alphafold

Sestrin-2 (SESN2)

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190).

Binding of leucine into SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses.

Gene Information

Human
Gene Name:	SESN2
Uniprot:	P58004
Entrez:	83667

Family

Belongs to:

sestrin family

Alternative Names

DKFZp761M0212; DKFZp761M02121; Hi95; HI95sestrin-2; SES2; SEST2hypoxia induced gene 95; sestrin 2

Molecular Weight

Mass (kDA):
54.494 kDA

Genomic Context


Human

Location:	1p35.3
Sequence:	1; NC_000001.11 (28259452..28282491)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Hypoxia
Mammary Neoplasms
Genomic Instability
Anoxia
Cell Transformation, Neoplastic
Obesity
Hereditary Hemorrhagic Telangiectasia
Melanoma
Malignant Neoplasm Of Breast
Ataxia

Glioma
Lung Diseases
Sarcoma
Carcinoma
Lung Diseases, Obstructive
Pulmonary Emphysema
Lymphoma

Interacting Proteins

KEAP1
MIOS
RBX1
Rbx1
SQSTM1

Ulk1
WDR24

Pathways

Cell Cycle
Cell Growth
Aging
Cell Proliferation
Autophagy
Cell Death
Rna Interference
Cell Cycle Arrest
Sensitization
Energy Homeostasis
Pathogenesis
Transport
Programmed Cell Death

Gene Silencing
Fibroblast Proliferation
Regulation Of Gene Expression
Macroautophagy
Histone Acetylation
Cell Differentiation
Response To Stress

PTMs

Phosphorylation
Reduction
Cleavage

Acetylation
Citrullination
Oxidation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SESN2

References

PMID: 12203114 by Budanov A.V., et al. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

PMID: 12607115 by Peeters H., et al. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.