SERTAD2 Antibodies

AND SERTAD2 ELISA kits, SERTAD2 Proteins

Many biological assays use antibodies to detect SERTAD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SERTAD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SERTAD2 antibodies...

We validate the specificity of these antibodies to SERTAD2 by testing them on tissues known to express SERTAD2 positively and negatively. Browse below to find the SERTAD2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SERTAD2 Infographic by Boster Bio

All SERTAD2 Products

Product

Figures

Specificity

Applications

Price

Human SERTAD2 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ14140
Starting from 4ug

SERTAD2 (NM_014755) Human Over-expression Lysate

Human

$628
Cat # LS009792
100 µg

SERTAD2 Overview

Facts about SERTA domain-containing protein 2.

SERTAD2 3D structure. Source: alphafold

SERTA domain-containing protein 2 (SERTAD2)

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- or bromodomain-containing transcription factors. May act as coactivator in addition to corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F- target genes expression.

Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. .

Gene Information

Human
Gene Name:	SERTAD2
Uniprot:	Q14140
Entrez:	9792

Family

Belongs to:

No superfamily

Alternative Names

KIAA0127; MGC126688; Sei-2; SERTA domain containing 2; SERTA domain-containing protein 2; Transcriptional regulator interacting with the PHD-bromodomain 2; transcriptional regulator interacting with the PHS-bromodomain 2; TRIP-Br2MGC126690

Molecular Weight

Mass (kDA):
33.897 kDA

Genomic Context


Human

Location:	2p14
Sequence:	2; NC_000002.12 (64631621..64751086, complement)

Tissue Specificity

Expressed in adipose tissue.

Subcellular Localizations

Nucleus. Cytoplasm. Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.

Diseases

Cell Transformation, Neoplastic
Retinoblastoma
Malignant Neoplasms
Neoplasms
Liver Carcinoma
Genomic Instability
Colorectal Cancer

Hyperplasia
Carcinoma

Pathways

Cell Cycle
Dna Replication
Regulation Of Cell Cycle
Cell Proliferation
Histone Acetylation
Proteolysis
Nuclear Export

Rna Interference
Oncogenesis

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERTAD2

References

PMID: 11331592 by Hsu S.-I., et al. TRIP-Br: a novel family of PHD zinc finger- and bromodomain- interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.

PMID: 18316374 by Cheong J.K., et al. CRM1-mediated nuclear export is required for 26 S proteasome- dependent degradation of the TRIP-Br2 proto-oncoprotein.