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- Table of Contents
Facts about Plasma protease C1 inhibitor.
Activation of the C1 complex is under control of the C1- inhibitor.
It creates a proteolytically inactive stoichiometric complex with the C1r or C1s proteases.May play a potentially crucial role in regulating significant physiological pathways such as complement activation, blood coagulation, fibrinolysis and the creation of kinins. Very efficient inhibitor of FXIIa.
Human | |
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Gene Name: | SERPING1 |
Uniprot: | P05155 |
Entrez: | 710 |
Belongs to: |
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serpin family |
C1 Inhibitor; C1IN; C1INH; C1NH; HAE1; HAE2; Serpin G1; SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Mass (kDA):
55.154 kDA
Human | |
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Location: | 11q12.1 |
Sequence: | 11; NC_000011.10 (57597685..57614848) |
Secreted.
PMID: 3488058 by Que B.G., et al. Isolation and analysis of a cDNA coding for human C1 inhibitor.
PMID: 3756141 by Bock S.C., et al. Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization.