Heparin cofactor 2 Antibodies

AND SERPIND1 ELISA kits, Heparin cofactor 2 Proteins

Many biological assays use antibodies to detect Heparin cofactor 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Heparin cofactor 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Heparin cofactor 2 antibodies...

We validate the specificity of these antibodies to Heparin cofactor 2 by testing them on tissues known to express SERPIND1 positively and negatively. Browse below to find the SERPIND1 antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SERPIND1 Infographic by Boster Bio

All SERPIND1 Products

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Specificity

Applications

Price

Anti-Heparin Cofactor II Antibody

13 Q&As

Human, Mouse, Rat

$360
Cat # A04607
100 µl

Human Serpin D1 ELISA Kit PicoKine®

9 Q&As

Human

ELISA

$499
Cat # EK1968
96 wells/kit, with removable strips.

Mouse Serpin D1 ELISA Kit PicoKine®

8 Q&As

Mouse

ELISA

$499
Cat # EK1969
96 wells/kit, with removable strips.

Rat Serpin D1 ELISA Kit PicoKine®

8 Q&As

Rat

ELISA

$499
Cat # EK1970
96 wells/kit, with removable strips.

Anti-HC-II (D68) SERPIND1 Antibody

Human, Mouse, Rat

IHC

$405
Cat # A04607-1
100ul

Anti-HC-II SERPIND1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A04607-2
100ul

Human Serpin D1/Heparin cofactor II Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTP05546
Starting from 20ug

Anti-SERPIND1 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A04607-3
100 µg/vial

SERPIND1 Overview

Facts about Heparin cofactor 2.

SERPIND1 3D structure. Source: alphafold

Heparin cofactor 2 (SERPIND1)

Thrombin inhibitor activated from the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III).

Also inhibits chymotrypsin, but in a glycosaminoglycan-independent method. .

Gene Information

Human
Gene Name:	SERPIND1
Uniprot:	P05546
Entrez:	3053

Family

Belongs to:

serpin family

Alternative Names

HC2; HC2LS2; HCF2; HCF2clade D (heparin cofactor), member 1; HC-II; Heparin Cofactor II; HLS2HCII; leuserpin 2; LS2; Protease inhibitor leuserpin-2; Serpin D1; serpin peptidase inhibitor, clade D (heparin cofactor), member 1

Molecular Weight

Mass (kDA):
57.071 kDA

Genomic Context


Human

Location:	22q11.21
Sequence:	22; NC_000022.11 (20774113..20787720)

Tissue Specificity

Expressed predominantly in liver. Also present in plasma.

Diseases

Atherosclerosis
Cardiovascular Diseases
Malignant Neoplasms
Dental Plaque
Blood Coagulation Disorders
Thrombosis
Schizoaffective Disorder
Neoplasm Metastasis
Infarction
Pulmonary Embolism
Malignant Neoplasm Of Lung
Inflammatory Response

Digeorge Syndrome
Vascular System Injuries
Myocardial Infarction
Tumor Angiogenesis
Cat Eye Syndrome
Cerebrovascular Accident
Osteoporosis

Pathways

Coagulation
Osteoclast Differentiation
Growth Hormone Secretion
Tube Formation
Angiogenesis
Regulation Of Angiogenesis
Bone Resorption
Hormone Secretion

Inflammatory Response
Secretion

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPIND1

References

PMID: 2894851 by Blinder M.A., et al. Heparin cofactor II: cDNA sequence, chromosome localization, restriction fragment length polymorphism, and expression in Escherichia coli.

PMID: 1671335 by Herzog R., et al. Complete nucleotide sequence of the gene for human heparin cofactor II and mapping to chromosomal band 22q11.