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Alpha-1-antitrypsin Antibodies
AND SERPINA1 ELISA kits, Alpha-1-antitrypsin Proteins
Many biological assays use antibodies to detect Alpha-1-antitrypsin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-1-antitrypsin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-1-antitrypsin antibodies...
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SERPINA1 Infographic by Boster Bio
All SERPINA1 Products
Product
Figures
Specificity
Applications
Price
Anti-alpha 1 Antitrypsin/SERPINA1 Antibody Picoband®
2 Citations 1 Q&As
Mouse, Rat
IHC, WB
$370
Cat # PB9354
100 μg/vial
Cat # PB9354
100 μg/vial
Human, Rat
WB
$370
Cat # PB10097
100 μg/vial
Cat # PB10097
100 μg/vial
Anti-Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) Monoclonal Antibody
2 Citations 7 Q&As
Human
IHC, WB
$486
Cat # M00720
100ug/vial
Cat # M00720
100ug/vial
Human
IP, IF, IHC, ICC, WB
$370
Cat # M00720-1
100 μl
Cat # M00720-1
100 μl
Human
ELISA
$499
Cat # EK1634
96 wells/kit, with removable strips.
Cat # EK1634
96 wells/kit, with removable strips.
Dog, Human, Monkey
Flow Cytometry, IP, IHC, WB
$523
Cat # M00720-3
100 µl
Cat # M00720-3
100 µl
Human
$628
Cat # LS005265
100 µg
Cat # LS005265
100 µg
SERPINA1 Overview
Facts about Alpha-1-antitrypsin.
Alpha-1-antitrypsin (SERPINA1)
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and contains proteolytic activity against insulin and plasmin.
Gene Information
| Human | |
|---|---|
| Gene Name: | SERPINA1 |
| Uniprot: | P01009 |
| Entrez: | 5265 |
Family
| Belongs to: |
|---|
| serpin family |
Alternative Names
A1A; A1AT; AATMGC23330; alpha 1-Antitrypsin; alpha 1-Proteinase Inhibitor; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; alpha-1-antitrypsin; antitrypsin), member 1; member 1; PIMGC9222; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase; serine (or cysteine) proteinase inhibitor, clade A, member 1; Serpin A1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
Molecular Weight
Mass (kDA):
46.737 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.13 |
| Sequence: | 14; NC_000014.9 (94376747..94390654, complement) |
Tissue Specificity
Ubiquitous. Expressed in leukocytes and plasma.
Subcellular Localizations
Secreted. Endoplasmic reticulum. The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.; [Short peptide from AAT]: Secreted, extracellular space, extracellular matrix.
Diseases
- Alpha 1-antitrypsin Deficiency
- Pulmonary Emphysema
- Lung Diseases
- Chronic Obstructive Airway Disease
- Liver Diseases
- Lung Diseases, Obstructive
- Malignant Neoplasms
- Carcinoma
- Inflammation
- Liver Cirrhosis
- Neoplasms
- Hereditary Diseases
- Liver Carcinoma
Interacting Proteins
- SSR1
Pathways
- Pathogenesis
- Immune Response
- Secretion
- Localization
- Cell Proliferation
- Glycosylation
- Cell Death
- Cell Adhesion
- Cell Migration
- Secretory Pathway
- Response To Stress
- Regeneration
- Proteolysis
PTMs
- Cleavage
- Glycosylation
- Phosphorylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPINA1
bosterbio.com/bosterbio-gene-info-cards/SERPINA1
References
PMID: 6319097 by Bollen A., et al. Cloning and expression in Escherichia coli of full-length complementary DNA coding for human alpha 1-antitrypsin.
PMID: 6093867 by Long G.L., et al. Complete sequence of the cDNA for human alpha 1-antitrypsin and the gene for the S variant.
3 Publications of Boster Alpha-1-antitrypsin Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.jprot.2016.08.013, Label-free proteomic analysis of placental proteins during Toxoplasma gondii inf...
- PubMed ID: 30440141, Clinical and pathological characteristics of IgG4%u2011related interstitial lung...
- PubMed ID: 29434730, Lv X, Gao F, Liu Q, Zhang S, Huang Z, Zhu Y, Zong H, Li Q, Li S. Exp Ther Med. 2...
*More publications can be found for each product on its corresponding product page