Serpin B6 Antibodies

AND SERPINB6 ELISA kits, Serpin B6 Proteins

Many biological assays use antibodies to detect Serpin B6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serpin B6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serpin B6 antibodies...

We validate the specificity of these antibodies to Serpin B6 by testing them on tissues known to express SERPINB6 positively and negatively. Browse below to find the SERPINB6 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SERPINB6 Infographic by Boster Bio

All SERPINB6 Products

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Product

Figures

Specificity

Applications

Price

Anti-Serpin B6 Antibody

Human, Mouse, Rat

$405
Cat # A07155
100ul

Anti-SPB6 SERPINB6 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A07155-1
100ul

SERPINB6 (NM_004568) Human Recombinant Protein

$813
Cat # PROTP35237
20 µg

Anti-SERPINB6 Mouse Monoclonal Antibody [Clone ID: OTI1C5]

Human, Monkey, Mouse

Flow Cytometry, IHC, WB

$523
Cat # M07155
100 µl

Anti-SERPINB6 Mouse Monoclonal Antibody [Clone ID: OTI3H3]

Human, Monkey, Mouse

Flow Cytometry, IF, WB

$523
Cat # M07155-1
100 µl

SERPINB6 (NM_004568) Human Over-expression Lysate

Human

$628
Cat # LS005269
100 µg

SERPINB6 Overview

Facts about Serpin B6.

SERPINB6 3D structure. Source: alphafold

Serpin B6 (SERPINB6)

May be involved in the regulation of serine proteinases present in the brain or extravasated from the bloodstream (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin.

May play an essential role in the inner ear in the defense against leakage of lysosomal content through stress and loss of this protection leads to cell death and sensorineural hearing loss. .

Gene Information

Human
Gene Name:	SERPINB6
Uniprot:	P35237
Entrez:	5269

Family

Belongs to:

serpin family

Alternative Names

CAP; CAPMGC111370; Cytoplasmic antiproteinase; deafness, autosomal recessive 91; DFNB91; Peptidase inhibitor 6; PI6; PI-6; PI6MSTP057; Placental thrombin inhibitor; protease inhibitor 6 (placental thrombin inhibitor); PTI; PTIDKFZp686I04222; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; Serpin B6; serpin peptidase inhibitor, clade B (ovalbumin), member 6; SPI3

Molecular Weight

Mass (kDA):
42.622 kDA

Genomic Context


Human

Location:	6p25.2
Sequence:	6; NC_000006.12 (2948159..2971793, complement)

Tissue Specificity

Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.

Subcellular Localizations

Cytoplasm.

Diseases

Inflammation
Neoplasms
Complete Hearing Loss
Candidiasis
Brain Ischemia
Atresia
Tumor Progression
Malignant Tumor Of Colon
Endometrial Polyp
Mastocytosis
Disseminated Candidiasis
Immunologic Deficiency Syndromes

Tumor Angiogenesis
Malignant Neoplasms
Cerebrovascular Accident
Chromosome Breakage
Colorectal Cancer
Cerebral Ischemia

Pathways

Cell Death
Localization
Coagulation
Fibrinolysis
Fertilization
Angiogenesis

Gonad Development

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPINB6

References

PMID: 8415716 by Coughlin P., et al. Cloning and molecular characterization of a human intracellular serine proteinase inhibitor.

PMID: 8136380 by Morgenstern K.A., et al. Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases.