Septin-2 Antibodies

AND SEPTIN2 ELISA kits, Septin-2 Proteins

Many biological assays use antibodies to detect Septin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Septin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Septin-2 antibodies...

We validate the specificity of these antibodies to Septin-2 by testing them on tissues known to express SEPTIN2 positively and negatively. Browse below to find the SEPTIN2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SEPTIN2 Infographic by Boster Bio

All SEPTIN2 Products

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Product

Figures

Specificity

Applications

Price

Septin 2 (SEPT2) (NM_004404) Human Recombinant Protein

$813
Cat # PROTQ15019
20 µg

Anti-Septin 2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M34007
100 μl/vial

Anti-Septin 2/SEPTIN2 Antibody Picoband®

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A34007
100 μg/vial

Septin 2 (SEPT2) (NM_001008491) Human Over-expression Lysate

Human

$628
Cat # LS004735
100 µg

SEPTIN2 Overview

Facts about Septin-2.

SEPTIN2 3D structure. Source: alphafold

Septin-2 (SEPTIN2)

Filament-forming cytoskeletal GTPase.
Types a filamentous arrangement with SEPT12, SEPT6, SEPT2 and likely SEPT4 at the sperm annulus that's required for the structural integrity and motility of the sperm tail through postmeiotic distinction (PubMed:25588830).

Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin.

Gene Information

Human
Gene Name:	SEPTIN2
Uniprot:	Q15019
Entrez:	4735

Family

Belongs to:

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily

Alternative Names

Septin-2

Molecular Weight

Mass (kDA):
41.487 kDA

Genomic Context


Human

Location:	2q37.3
Sequence:	2; NC_000002.12 (241315187..241354027)

Tissue Specificity

Widely expressed. Up-regulated in liver cancer.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane. Cell projection, cilium, flagellum. In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading

Interacting Proteins

PLEKHF2

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEPTIN2

References

PMID: 8697812 by Mori T., et al. Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6.

PMID: 15150837 by She Y.M., et al. Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo.