Septin-12 Antibodies

AND SEPTIN12 ELISA kits, Septin-12 Proteins

Many biological assays use antibodies to detect Septin-12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Septin-12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Septin-12 antibodies...

We validate the specificity of these antibodies to Septin-12 by testing them on tissues known to express SEPTIN12 positively and negatively. Browse below to find the SEPTIN12 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SEPTIN12 Infographic by Boster Bio

All SEPTIN12 Products

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SEPTIN12 (NM_144605) Human Recombinant Protein

$1249
Cat # PROTQ8IYM1
20 µg

Anti-SEPTIN12 Antibody Picoband®

Human, Mouse, Rat

ELISA, WB

$370
Cat # A12342-2
100 μg/vial

SEPTIN12 Overview

Facts about Septin-12.

SEPTIN12 3D structure. Source: alphafold

Septin-12 (SEPTIN12)

Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis.

Involved in the morphogenesis of sperm heads as well as the elongation of sperm tails likely implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous arrangement with SEPT7, SEPT6, SEPT2 and likely SEPT4 at the sperm annulus which is needed for the structural integrity and motility of the sperm tail through postmeiotic distinction (PubMed:25588830).

Gene Information

Human
Gene Name:	SEPTIN12
Uniprot:	Q8IYM1
Entrez:	124404

Family

Belongs to:

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily

Alternative Names

Septin-12

Molecular Weight

Mass (kDA):
40.748 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (4777590..4791610, complement)

Tissue Specificity

Widely expressed. Expressed in lymph node.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Nucleus. Cell projection, cilium, flagellum. At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus. Colocalized with SPAG4 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa.

Interacting Proteins

SPAG4

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEPTIN12

References

PMID: 17685441 by Steels J.D., et al. Sept12 is a component of the mammalian sperm tail annulus.

PMID: 18047794 by Ding X., et al. SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells.