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- Table of Contents
Facts about Sentrin-specific protease 6.
Deconjugates SUMO1 from RXRA, resulting in transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complicated.
Human | |
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Gene Name: | SENP6 |
Uniprot: | Q9GZR1 |
Entrez: | 26054 |
Belongs to: |
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peptidase C48 family |
EC 3.4.22.-; KIAA0797FLJ11887; Sentrin/SUMO-specific protease SENP6; sentrin-specific protease 6; SSP1KIAA0389; SUMO1/sentrin specific peptidase 6,2810017C20Rik; SUMO1/sentrin specific protease 6; SUMO-1-specific protease 1; SUSP1FLJ11355
Mass (kDA):
126.146 kDA
Human | |
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Location: | 6q14.1 |
Sequence: | 6; NC_000006.12 (75601509..75718281) |
Highly expressed in reproductive organs, such as testis, ovary and prostate.
Nucleus.
PMID: 10806345 by Yeh E.T.H., et al. Ubiquitin-like proteins: new wines in new bottles.
PMID: 10799485 by Kim K.I., et al. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs.