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- Table of Contents
Facts about Semaphorin-7A.
Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an essential role in modulating inflammation and T-cell-mediated immune responses.
Human | |
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Gene Name: | SEMA7A |
Uniprot: | O75326 |
Entrez: | 8482 |
Belongs to: |
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semaphorin family |
CD108 antigen; CD108; CD108MGC126696; CDw108; H-SEMA-K1; H-Sema-L; JMH blood group antigen; JMH; John-Milton-Hargen human blood group Ag; MGC126692; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin)7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin)7A; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; Sema K1; Sema L; Sema7A; SEMAK1; SEMAL; SEMALJohn Milton Hagen blood group H-Sema K1; Semaphorin 7A; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); semaphorin K1; semaphorin L; s
Mass (kDA):
74.824 kDA
Human | |
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Location: | 15q24.1 |
Sequence: | 15; NC_000015.10 (74409284..74433958, complement) |
Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
PMID: 9721204 by Lange C., et al. New eukaryotic semaphorins with close homology to semaphorins of DNA viruses.
PMID: 10201933 by Yamada A., et al. Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108.