Semaphorin-3C Antibodies

Semaphorin-3C (SEMA3C)

Binds to plexin family members and plays a significant role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis.

Functions as attractant for developing axons, and thereby plays an significant role in axon growth and axon guidance (By similarity). .

Gene Information

Human
Gene Name:	SEMA3C
Uniprot:	Q99985
Entrez:	10512

Family

Belongs to:
semaphorin family

Alternative Names

(semaphorin) 3C; sema domain, immunoglobulin domain (Ig), short basic domain, secreted; Sema E; SEMA3C; SEMAE; Semaphorin 3C; Semaphorin E; semaphorin-3C; semaphorin-E; SEME

Molecular Weight

Mass (kDA):
85.207 kDA

Genomic Context

Human
Location:	7q21.11
Sequence:	7; NC_000007.14 (80742536..80922389, complement)

Tissue Specificity

Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Nervousness
• Neoplasms
• Tumor Angiogenesis
• Neoplasm Metastasis
• Cell Invasion
• Tissue Adhesions
• Crest Syndrome
• Carcinoma
• Inflammation
• Tumor Progression
• Malignant Neoplasm Of Breast

• Neoplasm Invasiveness
• Pathologic Neovascularization
• Malignant Paraganglionic Neoplasm
• Prostatic Neoplasms
• Truncus Arteriosus, Persistent
• Malignant Neoplasm Of Prostate
• Cell Transformation, Neoplastic

Pathways

• Angiogenesis
• Axon Guidance
• Cell Migration
• Innervation
• Developmental Process
• Brain Development
• Vasculogenesis
• System Development
• Transport
• Hair Follicle Development
• Organic Anion Transport
• Pigmentation
• Heart Valve Development

• Cell Proliferation
• Blood Vessel Development
• Cell Development
• Anion Transport
• Endocytosis
• Outflow Tract Morphogenesis
• Glomerular Filtration

PTMs

• Carboxylation
• Phosphorylation

• Cleavage
• Deiodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEMA3C

Best Uses Of The SEMA3C Marker

This article discusses SEMA3C's benefits and uses. It discusses how to detect this marker and what types of tests can be performed with it. It also covers the testing requirements and recording results on autoradiography film or CHEMIDOC. It is applicable to all scientists around the world. Here are some benefits of this marker. They may prove to be useful in future.

Benefits of the SEMA3C Marker

The SEMA3C indicator is a useful biomarker to detect hair follicles. The expression of SEMA3C in the hair follicle is tightly associated with that of the lanceolate complex. It may play a role in the establishment and maintenance of the lanceolate complex in the hair follicle. We will discuss below the benefits of using SEMA3C to study hair follicles.

The SEMA3C Marker allows you to identify cells which express the protein. This marker has been used to identify a number of genes that are essential for the growth of healthy hearts and in the development of heart disease. SEMA3C can be used in research as well as being an important marker for diagnosing heart disease-related conditions. Its expression in cardiac NCCs may facilitate endoMT of the OFT.

SEMA3C has been shown to be associated with poor survival rates and tumor progression in various types of cancer. SEMA3C is thought to be involved in p -ERK signaling. SEMA3C's effects on cervical cancer cells have been validated in vitro and in vivo using assays. Moreover, the SEMA3C Marker is associated with angiogenesis and epithelial-mesenchymal transition, which are key mechanisms in the development of cancer.

Poor survival rates have been linked with the SEMA3C Marker in cervical cancer patients. The SEMA3C gene is highly expressed by cervical cancer tumors. It is also associated to survival data. It has been shown to increase the risk of cervical cancer recurrence. The study was published in a number of peer-reviewed medical journals. It has attracted much attention. The researchers hope that the SEMA3C Marker could help them identify cervical cancer patients with poor prognosis.

Techniques for detecting it

The LETR1 lncRNA is a nuclear lncRNA which regulates cell proliferation and migration. It also interacts with essential epigenetic partners such as RBBP7. It regulates the expression of distinct target genes, such as the semaphorin SEMA3C. This article explains the techniques for detecting SEMA3C Marker. This research shows that LETR1 regulates cells' growth and migration, and tunes expression of distinct target genes including KLF4 (SEMA3C).

The Sema3C gene is important in hepatic metastasis, which is an integral part the GC. The gene is also a biomarker for the condition and has clinical significance. This research reveals that Sema3C transcription is associated with GC metastasis and hepatic meetastasis.

It is up for you to test it.

SEMA3C is a member of the Semaphorin family of proteins and has been associated with virtually every Hallmark of Cancer. This protein is implicated both in GC hepatic metastasis and in the promotion of prostate cancer, as well as glioma stem cell development. As patients get older, the protein's functions diminish. It may be helpful to monitor the progression and treatment of hepatic cancers.

RWPE-1 SEMA3C spheres formed better than those of the parental RWPE-1. They were also twice as invasive in SEMA3C-containing media than controls. In addition, RWPE-1-SEMA3C cells exhibited enhanced levels of SEMA3C expression when compared to their adhered counterparts. Overexpressions of SEMA3C are thought to promote stem-like cells proliferation.

The SEMA3C mark is an essential component of the analysis and interpretation of human brain tissue. It allows you to determine if Sema3C is present within a human cells. This marker is vital in stem cell development and can be used to select patients. A large database that tracks the expression of SEMA3C during human developmental stages provides a framework to test the SEMA3C Marker.

The SEMA3C indicator was purified using reverse transcription of totalRNA. The mRNA was then quantified with SYBR PremixEx Taq. These parameters are the same as those used to calculate the ACTB-standard curve. This information provides additional information regarding the efficacy SEMA3C's-based PCR. It is important that this marker has been confirmed as a reliable diagnostic tool in the detection of cancer.

Sema3C knockdown significantly reduced the number of migrated cell in a mouse model. Sema3C knockdown did not affect the ER, but it did reduce the number GTP binding Rac1 cells. It is therefore important to confirm that the SEMA3C marker is accurate in your patient. It is crucial to determine the level of the SEMA3C markers in your patient to assess the cellular response.

Tests to record on autoradiography film (or CHEMIDOC)

Autoradiography is a process in which a radioactive substance is bound to an enzyme, nucleic acid, or receptor. Autoradiography can be used for many purposes, including environmental and biomedical. In addition to determining tissue location, autoradiography is also used in many other applications. Here are some examples of the most used applications. For more information visit the Autoradiography section in the UCSD Medical Library.