SCUBE3 Antibodies

AND SCUBE3 ELISA kits, SCUBE3 Proteins

Many biological assays use antibodies to detect SCUBE3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCUBE3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCUBE3 antibodies...

We validate the specificity of these antibodies to SCUBE3 by testing them on tissues known to express SCUBE3 positively and negatively. Browse below to find the SCUBE3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SCUBE3 Infographic by Boster Bio

All SCUBE3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-SCUBE3 Antibody

Human

ELISA, IHC-P

$449
Cat # A09090
0.1 mg

Anti-SCUBE3 Antibody

Human, Mouse

ELISA, IF, WB

$449
Cat # A09090-1
0.1 mg

SCUBE3 (NM_152753) Human Over-expression Lysate

Human

$628
Cat # LS222663
100 µg

SCUBE3 Overview

Facts about Signal peptide, CUB and EGF-like domain-containing protein 3.

SCUBE3 3D structure. Source: alphafold

Signal peptide, CUB and EGF-like domain-containing protein 3 (SCUBE3)

Binds to TGFBR2 and activates TGFB signaling.
In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which might regulate TGFBR2 signaling and thus modulate epithelial-mesenchymal transition and cancer development.

Gene Information

Human
Gene Name:	SCUBE3
Uniprot:	Q8IX30
Entrez:	222663

Family

Belongs to:

No superfamily

Alternative Names

CEGF3; CUB and EGF containing protein 3; CUB domain and EGF-like repeat containing 3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743; SCUBE3; signal peptide, CUB and EGF-like domain containing protein 3; signal peptide, CUB and EGF-like domain-containing protein 3; signal peptide, CUB domain, EGF-like 3

Molecular Weight

Mass (kDA):
109.282 kDA

Genomic Context


Human

Location:	6p21.31
Sequence:	6; NC_000006.12 (35213956..35253079)

Tissue Specificity

Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.

Subcellular Localizations

Secreted. Cell surface.

Diseases

Malignant Neoplasms
Neoplasms
Cell Invasion
Cell Transformation, Neoplastic
Neoplasm Metastasis
Osteitis Deformans
Lung Neoplasms
Cardiac Hypertrophy
Kidney Neoplasm
Neoplasm Invasiveness
Malignant Neoplasm Of Lung

Carcinoma
Left Ventricular Hypertrophy
Hypertrophy
Renal Cell Carcinoma
Bone Diseases
Metabolic Bone Disorder

Interacting Proteins

MMP2
MMP9
TGFBR2

Pathways

Methylation
Glycosylation

PTMs

Phosphorylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCUBE3

References

PMID: 15234972 by Wu B.-T., et al. A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones.

PMID: 21441952 by Wu Y.Y., et al. SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer.