Scube2 Antibodies

AND Scube2 ELISA kits, Scube2 Proteins

Many biological assays use antibodies to detect Scube2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Scube2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Scube2 antibodies...

We validate the specificity of these antibodies to Scube2 by testing them on tissues known to express Scube2 positively and negatively. Browse below to find the Scube2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Scube2 Infographic by Boster Bio

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Anti-SCUBE2 Antibody

Human, Rat

ELISA, IF, ICC, WB

$449
Cat # A09179
0.1 mg

Scube2 Overview

Facts about Signal peptide, CUB and EGF-like domain-containing protein 2.

Signal peptide, CUB and EGF-like domain-containing protein 2 (Scube2)

Lipid-binding protein required for SHH long-lived signaling by binding to the dually lipid-modified SHH (ShhNp) and by encouraging ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by improving the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp in the cell surface (PubMed:24522195).

Synergizes with DISP1 to cause a boost in SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved with VEGFR2-mediated angiogenesis (PubMed:27834687).

Gene Information

Mouse
Gene Name:	Scube2
Uniprot:	Q9JJS0
Entrez:	56788

Family

Belongs to:

No superfamily

Alternative Names

Cegb1; CEGF1; CEGP1; FLJ16792; FLJ35234; MGC133057; Protein CEGP1; signal peptide, CUB and EGF-like domain-containing protein 2; signal peptide, CUB domain, EGF-like 2

Molecular Weight

Mass (kDA):
109.924 kDA

Genomic Context


Mouse

Location:	7 E3\|7 57.53 cM
Sequence:	7;

Tissue Specificity

Expressed in adult heart, lung and testis.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Tumor Progression
Carcinoma
Nervousness
Neoplasm Metastasis
Monoclonal Gammapathies
Monoclonal Gammopathy Of Undetermined Significance
Purpura, Thrombotic Thrombocytopenic
Tumor Angiogenesis

Thrombocytopenic Purpura
Chimera Disorder
Serous Retinal Detachment
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Retinal Detachment

Pathways

Cell Proliferation
Transport
Secretory Pathway
Spinal Cord Patterning
Organ Development
Glycosylation
Angiogenesis

Localization
Secretion

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Scube2

References

PMID: 11528127 by Amid C., et al. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.

PMID: 11287194 by Grimmond S., et al. Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development.