Rnf128 Antibodies

AND Rnf128 ELISA kits, Rnf128 Proteins

Many biological assays use antibodies to detect Rnf128, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Rnf128 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Rnf128 antibodies...

We validate the specificity of these antibodies to Rnf128 by testing them on tissues known to express Rnf128 positively and negatively. Browse below to find the Rnf128 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Rnf128 Infographic by Boster Bio

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Rnf128 Overview

Facts about E3 ubiquitin-protein ligase RNF128.

E3 ubiquitin-protein ligase RNF128 (Rnf128)

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription.

Inhibits IL2 and IL4 transcription, thereby playing a significant role in the induction of the anergic phenotype, a long-term steady state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with'Lys- 48' linkages and COR1A with'Lys-63' linkages leading to their degradation, down-regulation of those cytosleletal components leads to impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse.

Gene Information

Mouse
Gene Name:	Rnf128
Uniprot:	Q9D304
Entrez:	66889

Family

Belongs to:

No superfamily

Alternative Names

EC 6.3.2; EC 6.3.2.-; FLJ23516; Gene related to anergy in lymphocytes protein; GRAIL; ring finger protein 128GRAILE3 ubiquitin-protein ligase RNF128; RNF128

Molecular Weight

Mass (kDA):
46.276 kDA

Genomic Context


Mouse

Location:	X\|X F1
Sequence:	X;

Tissue Specificity

Expressed in brain, kidney, heart, liver, ovary, testis and thymus. Expression increased as early as 4 hours by 5- to 7-fold in anergized cultures as compared to resting or activated cells.

Diseases

Autoimmune Diseases
Autoimmunity
Autoimmune Reaction
Radiation Chimera Disorder

Pathways

Cell Activation
Tolerance Induction
Cytokine Production
T Cell Activation
T Cell Anergy
T Cell Tolerance Induction

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rnf128

References

PMID: 12435366 by Borchers A.G.M., et al. The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development.

PMID: 12705856 by Anandasabapathy N., et al. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.