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- Table of Contents
Facts about Arginine-glutamic acid dipeptide repeats protein.
Overexpression of RERE recruits BAX into the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. .
Human | |
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Gene Name: | RERE |
Uniprot: | Q9P2R6 |
Entrez: | 473 |
Belongs to: |
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No superfamily |
ARGARPKIAA0458arginine-glutamic acid dipeptide repeats protein; arginine-glutamic acid dipeptide (RE) repeats; ATN1L; atrophin 2; atrophin-1 like protein; atrophin-1 related protein; Atrophin-1-like protein; Atrophin-1-related protein; DNB1; FLJ38775
Mass (kDA):
172.424 kDA
Human | |
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Location: | 1p36.23 |
Sequence: | 1; NC_000001.11 (8352404..8817640, complement) |
Widely expressed. Expressed in tumor cell lines.
Nucleus. Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
PMID: 10814707 by Yanagisawa H., et al. Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine.
PMID: 11331249 by Waerner T., et al. Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis.