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- Table of Contents
Facts about Rabenosyn-5.
Plays a role in the lysosomal trafficking of CTSD/cathepsin D in the Golgi to lysosomes. Also promotes the recycling of transferrin straight from early endosomes to the plasma membrane.
Human | |
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Gene Name: | RBSN |
Uniprot: | Q9H1K0 |
Entrez: | 64145 |
Belongs to: |
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No superfamily |
110 kDa protein; FLJ34993; FYVE finger-containing Rab5 effector protein rabenosyn-5; FYVE-finger-containing Rab5 effector protein rabenosyn-5; MGC126210; Rabenosyn-5; ZFYVE20; Zinc finger FYVE domain-containing protein 20; zinc finger, FYVE domain containing 20
Mass (kDA):
88.87 kDA
Human | |
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Location: | 3p25.1 |
Sequence: | 3; NC_000003.12 (15070069..15099163, complement) |
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface.
PMID: 11062261 by Nielsen E., et al. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.
PMID: 11788822 by de Renzis S., et al. Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.
*More publications can be found for each product on its corresponding product page