RNA-binding protein 38 (RBM38)

RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of their p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest.

Isoform 1, but not isoform 2, has the capacity to induce cell cycle arrest in G1 and take care of the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor.