RASGRP2 Antibodies

AND RASGRP2 ELISA kits, RASGRP2 Proteins

Many biological assays use antibodies to detect RASGRP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RASGRP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RASGRP2 antibodies...

We validate the specificity of these antibodies to RASGRP2 by testing them on tissues known to express RASGRP2 positively and negatively. Browse below to find the RASGRP2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RASGRP2 Infographic by Boster Bio

All RASGRP2 Products

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RASGRP2 (NM_153819) Human Recombinant Protein

$1062
Cat # PROTQ7LDG7
20 µg

RASGRP2 (NM_153819) Human Over-expression Lysate

Human

$960
Cat # LS010235
100 µg

RASGRP2 Overview

Facts about RAS guanyl-releasing protein 2.

RASGRP2 3D structure. Source: alphafold

RAS guanyl-releasing protein 2 (RASGRP2)

Functions as a calcium- and DAG-regulated nucleotide exchange factor especially activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS.

Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils likely through inside-out integrin activation. May be the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.

Gene Information

Human
Gene Name:	RASGRP2
Uniprot:	Q7LDG7
Entrez:	10235

Family

Belongs to:

RASGRP family

Alternative Names

Calcium and DAG-regulated guanine nucleotide exchange factor I; CALDAG-GEFI; CDC25Lcalcium and diacylglycerol-regulated guanine nucleotide exchange factor I; Cdc25-like protein; F25B3.3 kinase-like protein; guanine exchange factor MCG7; hCDC25L; MCG7; RAS guanyl nucleotide-releasing protein 2; RAS guanyl releasing protein 2 (calcium and DAG-regulated); RAS guanyl-releasing protein 2

Molecular Weight

Mass (kDA):
69.248 kDA

Genomic Context


Human

Location:	11q13.1
Sequence:	11; NC_000011.10 (64726911..64745481, complement)

Tissue Specificity

Detected in platelets, neutrophils and T lymphocytes (at protein level). Expressed in brain where it is enriched in the striatum. Also expressed in the hematopoietic system. Detected in heart, brain, lung, placenta, liver, skeletal muscle and kidney.

Subcellular Localizations

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, ruffle membrane; Peripheral membrane protein. Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity).