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- Table of Contents
Facts about Ras-related protein Rab-7L1.
Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the whole central nervous system (CNS).
Human | |
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Gene Name: | RAB29 |
Uniprot: | O14966 |
Entrez: | 8934 |
Belongs to: |
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small GTPase superfamily |
Ras-related protein Rab-7L1
Mass (kDA):
23.155 kDA
Human | |
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Location: | 1q32.1 |
Sequence: | 1; NC_000001.11 (205767986..205775487, complement) |
Ubiquitous.
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:29212815). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847). Colocalizes with TGN46 at the trans-Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recr
PMID: 9284931 by Shimizu F., et al. Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily.
PMID: 22042847 by Spano S., et al. Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella.