Ras-related protein Rab-7L1 (RAB29)

Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of this endosome-trans- Golgi network structure.

Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the whole central nervous system (CNS).