Relaxin receptor 1 Antibodies

AND RXFP1 ELISA kits, Relaxin receptor 1 Proteins

Many biological assays use antibodies to detect Relaxin receptor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Relaxin receptor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Relaxin receptor 1 antibodies...

We validate the specificity of these antibodies to Relaxin receptor 1 by testing them on tissues known to express RXFP1 positively and negatively. Browse below to find the RXFP1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RXFP1 Infographic by Boster Bio

All RXFP1 Products

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Anti-Relaxin receptor 1 RXFP1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02783
100ul

LGR7 (RXFP1) (NM_021634) Human Over-expression Lysate

Human

$628
Cat # LS059350
100 µg

RXFP1 Overview

Facts about Relaxin receptor 1.

RXFP1 3D structure. Source: alphafold

Relaxin receptor 1 (RXFP1)

Receptor for relaxins.
The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP.

Binding of the ligand may also trigger a tyrosine kinase pathway that inhibits the action of a phosphodiesterase that degrades cAMP. .

Gene Information

Human
Gene Name:	RXFP1
Uniprot:	Q9HBX9
Entrez:	59350

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

leucine-rich repeat-containing G protein-coupled receptor 7; Leucine-rich repeat-containing G-protein coupled receptor 7; LGR7; LGR7.1; LGR7.10; LGR7LGR7.2; MGC138347; MGC142177; Relaxin family peptide receptor 1; Relaxin R1; relaxin receptor 1; relaxin/insulin-like family peptide receptor 1; RelaxinR1; RXFP1; RXFPR1

Molecular Weight

Mass (kDA):
86.975 kDA

Genomic Context


Human

Location:	4q32.1
Sequence:	4; NC_000004.12 (158521711..158653372)

Tissue Specificity

Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Endometrial Polyp
Neoplasms
Malignant Neoplasms
Fibrosis
Neoplasm Metastasis
Paroxysmal Nocturnal Dyspnea
Heart Failure
Inflammation
Malignant Neoplasm Of Prostate
Pertussis
Tumor Angiogenesis
Prostatic Neoplasms

Premature Birth
Infertility
Cell Invasion
Tissue Adhesions
Cardiac Failure Acute
Nervousness
Disease Of Adrenal Medulla

Interacting Proteins

AKAP5

Pathways

Cell Proliferation
Secretion
Localization
Parturition
Lactation
Spermatogenesis
Angiogenesis
Embryo Development
Glycosylation
Vasodilation
Cell Motility
Sertoli Cell Proliferation
Inflammatory Response

Wound Healing
Tissue Remodeling
Gland Development
Oocyte Maturation
Energy Homeostasis
Acrosome Reaction
Aging

PTMs

Phosphorylation

Glycosylation

Cleavage

Research Areas

GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RXFP1

References

PMID: 10935549 by Hsu S.Y., et al. The three subfamilies of leucine-rich repeat-containing G protein- coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7.

PMID: 16051677 by Muda M., et al. Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.