RuvB-like 2 Antibodies

AND RUVBL2 ELISA kits, RuvB-like 2 Proteins

Many biological assays use antibodies to detect RuvB-like 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RuvB-like 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RuvB-like 2 antibodies...

We validate the specificity of these antibodies to RuvB-like 2 by testing them on tissues known to express RUVBL2 positively and negatively. Browse below to find the RUVBL2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RUVBL2 Infographic by Boster Bio

All RUVBL2 Products

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Product

Figures

Specificity

Applications

Price

Anti-RuvB-like 2 RUVBL2 Antibody

Human, Mouse, Rat

$405
Cat # A02246
100ul

Anti-RUVBL2 Mouse Monoclonal Antibody [Clone ID: OTI1A6]

Dog, Human, Monkey, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M02246
100 µl

Anti-Reptin / RUVBL2 Rabbit Monoclonal Antibody

Human, Mouse

$370
Cat # M02246-1
100 μl/vial

RUVBL2 (NM_006666) Human Over-expression Lysate

Human

$628
Cat # LS010856
100 µg

RUVBL2 Overview

Facts about RuvB-like 2.

RUVBL2 3D structure. Source: alphafold

RuvB-like 2 (RUVBL2)

Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is supposed to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. .

Gene Information

Human
Gene Name:	RUVBL2
Uniprot:	Q9Y230
Entrez:	10856

Family

Belongs to:

RuvB family

Alternative Names

48 kDa TATA box-binding protein-interacting protein; 51 kDa erythrocyte cytosolic protein; EC 3.6.1; EC 3.6.4.12,48 kDa TBP-interacting protein; ECP51TIP49B; erythrocyte cytosolic protein, 51-KD; INO80 complex subunit J; INO80JTAP54-beta; Repressing pontin 52; Reptin 52; REPTIN; Reptin52; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. coli); ruvB-like 2; RVB2; TBP-interacting protein, 48-KD; TIH2; TIP48ECP-51; TIP49b; TIP60-associated protein 54-beta

Molecular Weight

Mass (kDA):
51.157 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (48993448..49015995)

Tissue Specificity

Ubiquitously expressed. Highly expressed in testis and thymus.

Subcellular Localizations

Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes.

Diseases

Malignant Neoplasms
Neoplasms
Aortic Aneurysm, Abdominal
Cell Transformation, Neoplastic
Liver Carcinoma
Carcinoma
Liver Neoplasms
Neoplasm Metastasis
Hypoxia
Immunologic Deficiency Syndromes
Carcinogenesis
Brain Ischemia
Malignant Neoplasm Of Breast

Malignant Tumor Of Colon
Malignant Tumor Of Cervix
Mammary Neoplasms
Autoimmune Diseases
Physiological Stress
Metaplastic Cell Transformation
Inflammation

Interacting Proteins

CCDC103
DPCD
EP400
LNX1
RUVBL1

Pathways

Chromatin Remodeling
Cell Growth
Cell Cycle
Cell Proliferation
Senescence
Oncogenesis
Dna Repair
Translation
Localization
Methylation
Pathogenesis
Aging
Immune Response

Double-strand Break Repair
Inflammatory Response
Response To Hypoxia
Mitosis
Pollen Germination
Cell Migration
M Phase

PTMs

Phosphorylation
Acetylation

Methylation
Sumoylation

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RUVBL2

References

PMID: 10524211 by Salzer U., et al. Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins.

PMID: 10428817 by Kanemaki M., et al. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a.