CYP46A1 Antibodies

AND CYP46A1 ELISA kits, CYP46A1 Proteins

Many biological assays use antibodies to detect CYP46A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CYP46A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CYP46A1 antibodies...

We validate the specificity of these antibodies to CYP46A1 by testing them on tissues known to express CYP46A1 positively and negatively. Browse below to find the CYP46A1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP46A1 Infographic by Boster Bio

All CYP46A1 Products

Product

Figures

Specificity

Applications

Price

Anti-Cholesterol 24-hydroxylase CYP46A1 Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A03772
100ul

CYP46 (CYP46A1) (NM_006668) Human Over-expression Lysate

Human

$628
Cat # LS010858
100 µg

CYP46A1 Overview

Facts about Cholesterol 24-hydroxylase.

CYP46A1 3D structure. Source: alphafold

Cholesterol 24-hydroxylase (CYP46A1)

Involved in the turnover of cholesterol.
It converts cholesterol to 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.

Has also action with xenobiotic compounds, such as clotrimazole. .

Gene Information

Human
Gene Name:	CYP46A1
Uniprot:	Q9Y6A2
Entrez:	10858

Family

Belongs to:

cytochrome P450 family

Alternative Names

CH24H; cholesterol 24-hydroxylase; CYP46CP46; Cytochrome P450 46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase); EC 1.14.13.98

Molecular Weight

Mass (kDA):
56.821 kDA

Genomic Context


Human

Location:	14q32.2
Sequence:	14; NC_000014.9 (99684262..99727321)

Tissue Specificity

Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse. Cell projection, dendrite.

Diseases

Alzheimer's Disease
Glaucoma
Nervousness
Impaired Cognition
Neurodegenerative Disorders
Atrophy
Nerve Degeneration
Dementia
Glaucoma, Open-angle
Mild Cognitive Disorder
Plaque, Amyloid
Primary Open Angle Glaucoma
Nervous System Disorder

Cognition Disorders
Sclerosis
Cerebral Atrophy
Hypercholesterolemia
Senile Plaques
Age Related Macular Degeneration
Neuroblastoma

Pathways

Cholesterol Homeostasis
Transport
Excretion
Secretion
Aging
Cholesterol Transport
Pathogenesis
Endosomal Transport
Protein Phosphorylation
Cholesterol Storage
Regulation Of Cholesterol Homeostasis
Immune Response
Membrane Organization

Neurogenesis
Localization
Inflammatory Response
Translation
Histone Acetylation
Phospholipid Homeostasis
Phospholipid Transport

PTMs

Hydroxylation
Cleavage
Phosphorylation

Acetylation
Demethylation
Methylation

Oxidation

Research Areas

Lipid and Metabolism
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP46A1

References

PMID: 10377398 by Lund E.G., et al. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.

PMID: 12077124 by Bodin K., et al. Metabolism of 4 beta -hydroxycholesterol in humans.