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RUNX2 Antibodies
AND RUNX2 ELISA kits, RUNX2 Proteins
Many biological assays use antibodies to detect RUNX2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RUNX2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RUNX2 antibodies...
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RUNX2 Infographic by Boster Bio
All RUNX2 Products
Product
Figures
Specificity
Applications
Price
Anti-RUNX2 Monoclonal Antibody
6 Citations 15 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00442
100 μl
Cat # M00442
100 μl
RUNX2 Overview
Facts about Runt-related transcription factor 2.
Runt-related transcription factor 2 (RUNX2)
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Critical for the maturation of osteoblasts and both intramembranous and endochondral ossification.
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive component (OCFRE) (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | RUNX2 |
| Uniprot: | Q13950 |
| Entrez: | 860 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Acute myeloid leukemia 3 protein; AML3CCD; CBFA1; CBFA1MGC120022; Core-binding factor subunit alpha-1; MGC120023; PEA2-alpha A; PEBP2A; PEBP2A1CCD1; PEBP2aA1; PEBP2-alpha A; runt domain, alpha subunit 1; runt-related transcription factor 2; RUNX2; SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit
Molecular Weight
Mass (kDA):
56.648 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.1 |
| Sequence: | 6; NC_000006.12 (45328317..45551082) |
Tissue Specificity
Specifically expressed in osteoblasts.
Subcellular Localizations
Nucleus.
Diseases
- Osteoporosis
- Neoplasms
- Malignant Neoplasms
- Hypertrophy
- Osteopenia
- Dysplasia
- Cleidocranial Dysplasia
- Fracture
- Osteosarcoma
- Neoplasm Metastasis
- Leukemia
- Bone Diseases
- Tissue Adhesions
Interacting Proteins
- PIN1
- PPM1D
- SMAD6
- TP73
- UBTF
Pathways
- Osteoblast Differentiation
- Cell Proliferation
- Regeneration
- Ossification
- Cell Differentiation
- Bone Development
- Bone Resorption
- Chondrocyte Differentiation
- Bone Remodeling
- Endochondral Ossification
- Localization
- Cell Growth
- Pathogenesis
PTMs
- Phosphorylation
- Acetylation
- Methylation
- Ubiquitination
- Cleavage
- Dephosphorylation
- Deacetylation
- Demethylation
- Reduction
Research Areas
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RUNX2
bosterbio.com/bosterbio-gene-info-cards/RUNX2
References
PMID: 9182765 by Mundlos S., et al. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia.
PMID: 9434946 by Geoffroy V., et al. Genomic organization, expression of the human CBFA1 gene, and evidence for an alternative splicing event affecting protein function.
13 Publications of Boster RUNX2 Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0150263, The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral O...
- PubMed ID: 32018039, Chen G,Wang Q,Li Z,Yang Q,Liu Y,Du Z,Zhang G,Song Y.Circular RNA CDR1as promotes...
- PubMed ID: 26918743, The transcription factor Hand1 is involved in Runx2-Ihh-regulated endochondral o...
- PubMed ID: 27069479, Effects of Intermittent Administration of Parathyroid Hormone (1-34) on Bone Dif...
- PubMed ID: 29213288, Yao S, Zhao W, Ou Q, Liang L, Lin X, Wang Y. Stem Cells Int. 2017;2017:3028647. ...
- PubMed ID: 28253279, Liu Q, Ma Y, Wang J, Zhu X, Yang Y, Mei Y. PLoS One. 2017 Mar 2;12(3):e0172693. ...
- PubMed ID: 21121067, Liu F, Zhong H, Liang Jy, Fu P, Luo Zj, Zhou L, Gou R, Huang J. J Zhejiang Univ ...
- PubMed ID: 25044369, Shan T, Zhou C, Yang R, Yan F, Zhang P, Fu Y, Jiang H. Cell Biol Int. 2015 Jan;3...
- PubMed ID: 22286010, Wang S, Mu J, Fan Z, Yu Y, Yan M, Lei G, Tang C, Wang Z, Zheng Y, Yu J, Zhang G....
- PubMed ID: 24826377, Mu C, Lv T, Wang Z, Ma S, Ma J, Liu J, Yu J, Mu J. Biomed Res Int. 2014;2014:494...
- PubMed ID: 23473758, Xue P, Wu X, Zhou L, Ma H, Wang Y, Liu Y, Ma J, Li Y. Biochem Biophys Res Commun...
- PubMed ID: 24068522, Song My, Yu Jz, Zhao Dm, Wei S, Liu Y, Hu Ym, Zhao Wc, Yang Y, Wu H. Cell Bioche...
- PubMed ID: 24421074, Li Jp, Chen S, Peng H, Zhou Jl, Fang Hs. Bioelectromagnetics. 2014 Apr;35(3):170...
*More publications can be found for each product on its corresponding product page