Reticulon-4 Antibodies

Reticulon-4 (RTN4)

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and expansion in the developing nervous system.

Involved in down-regulation of development, insertion of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons through an RTN4R-LINGO1 containing receptor complex (By similarity).

Gene Information

Human
Gene Name:	RTN4
Uniprot:	Q9NQC3
Entrez:	57142

Family

Belongs to:
No superfamily

Alternative Names

ASY; foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein C homolog; Neuroendocrine-specific protein; NI220/250; Nogo protein; NOGO-A; Nogo-B; NOGOC; Nogo-C; NOGORTN4-B1; NSP; NSP-CL; reticulon 4; reticulon 5; reticulon-4; reticulon-5; RTN4-A; RTN4-B2; RTN4-C; RTN-x

Molecular Weight

Mass (kDA):
129.931 kDA

Genomic Context

Human
Location:	2p16.1
Sequence:	2; NC_000002.12 (54972189..55137831, complement)

Tissue Specificity

Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis- specific.

Subcellular Localizations

[Isoform A]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein; Cytoplasmic side. Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM33 at the ER sheets.; [Isoform B]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein; Extracellular side. Cell junction. Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagemen

Diseases

• Nervousness
• Schizophrenia
• Alzheimer's Disease
• Neoplasms
• Neurodegenerative Disorders
• Tissue Adhesions
• Sclerosis
• Primary Lateral Sclerosis
• Amyotrophic Lateral Sclerosis
• Heart Diseases
• Depressive Disorder
• Rheumatic Heart Disease
• Impaired Cognition

• Congenital Heart Disease
• Plaque, Amyloid
• Cardiomyopathy, Dilated
• Heart Septal Defects
• Cardiomyopathies
• Glioma
• Glaucoma, Open-angle

Interacting Proteins

• ARL6IP1
• ATL1
• NCK2
• SNX1
• SNX15

• SYT16
• ZFYVE21

Pathways

• Regeneration
• Pathogenesis
• Cell Migration
• Localization
• Cell Adhesion
• Axon Regeneration
• Neurogenesis
• Cell Division
• Cell Death
• Membrane Organization
• Cerebellum Development
• Chemotaxis
• Translation

• Cell Differentiation
• Cell Communication
• Cell Proliferation
• Cell Development
• Cellular Process
• Synaptic Transmission
• Muscle Atrophy

PTMs

• Phosphorylation
• Cleavage

• Methylation
• Ubiquitination

Research Areas

• Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RTN4

Who Is Steven Boster?

You may be thinking, "Who is Steven Boster?" Continue reading to find out more about Boster as well as the RTN4 marker's benefits , and its the most effective uses. We will also go over Steven Boster's background and how you can apply it to your research.

Boster Bio: RTN4 Marker

Boster Bio's Anti-Bax Monoclonal Antibody was validated for use with ELISA, IHC and WB applications. This antibody reacts with both monkey and human samples. To ensure high sensitivity, it has been tested with multiple assays. Researchers and scientists are able to submit their results for species, applications and projects. Researchers may also submit research results to be eligible for credits on products.

RTN4 can be used to measure the levels of cellular genes in various cell types. It is exogenously expressed and can replace RTN3. Numerous cancer treatments, including immunotherapy and gene therapy are employing RTN4 in clinical trials. Cancer patients have the RTN4 gene expressed in their brains. Exogenously expressed RTN4 can be used to determine levels of specific tumor-associated proteins as well as to detect cancer.

The story of Steven Boster's past

Don "Steve" Boster was born in Joliet, IL. He died of COVID-19 on February 24 on the 24th of February, 2019 in Madison, WI. His children include Donald, Sr., David Boster, and Nina Mae Hall. His mother Frances lives in Verona, WI, and his siblings are Kimberly and Tammy. He also has one son, Jonathan, and a grandson Cory lives in Herrin, IL.

Applications of the RTN4 Marker

The RTN4 Marker is a useful tool for a variety of studies related to autophagy. Its role in autophagy is to facilitate the degradation of ER tubules via a specific autophagy pathway, which is initiated by the protein complex FAM134B and SEC62. It has multiple LC3-interacting sites and has been identified as a receptor responsible for ER tubule degradation. It is involved with the transport of ER tubules from lysosomes and their disintegration.

Several genes encode this protein that is distributed in the central nervous system. It is produced by neurons during the process of neural development and also blocks the growth of neurites. It also restricts blood vessel density by preventing the growth and migration of endothelial cells within the central nervous system. Their precise functions are not established. The uses of the RTN4 Marker are discussed below. These findings will help researchers identify the best subject for their research.

The RTN4 marker is a powerful marker to study neurodegenerative disorders in humans. It is a reliable biomarker that can be used to detect early Alzheimer's disease. It is now possible to recognize the various neurodegenerative diseases with molecular markers. It is used in a variety of research and could also have clinical applications. It can be used to identify certain diseases and to monitor patient progression. It can also be used to diagnose genetic disorders.

Numerous studies have implicated the RTN4 Marker in a variety of biological processes and functions. The Related Categories tab provides a detailed description of the functions of the RTN4 Marker. More research is needed to discover the exact role played by RTN4 in these processes. Numerous proteins play a role in its biological and functional functions. These researches highlight the importance of the RTN4 protein in the development of human diseases. However, there are many questions to be addressed before the RTN4 Marker can be widely used for the treatment of human neuroendocrine disorders.