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R-spondin-2 Antibodies
AND Rspo2 ELISA kits, R-spondin-2 Proteins
Many biological assays use antibodies to detect R-spondin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with R-spondin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop R-spondin-2 antibodies...
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Rspo2 Infographic by Boster Bio
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Rspo2 Overview
Facts about R-spondin-2.
R-spondin-2 (Rspo2)
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also functions as a ligand for frizzled and LRP receptors.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Rspo2 |
| Uniprot: | Q8BFU0 |
| Entrez: | 239405 |
Family
| Belongs to: |
|---|
| R-spondin family |
Alternative Names
Cristin 2; CRISTIN2; hRspo2; MGC35555; MGC43342; Roof plate-specific spondin-2; RSPO2; R-spondin 2 homolog (Xenopus laevis); RSpondin 2; R-Spondin 2; R-spondin-2
Molecular Weight
Mass (kDA):
28.276 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 15 B3.1-B3.2|15 16.73 cM |
| Sequence: | 15; |
Diseases
- Malignant Neoplasms
- Limb Deformities, Congenital
- Neoplasms
- Hypoplasia
- Cell Transformation, Neoplastic
- Colorectal Neoplasms
- Craniofacial Abnormalities
- Colorectal Cancer
- Hyperplasia
- Sclerosis
- Adenoma
- Primary Lateral Sclerosis
- Intraepithelial Neoplasia
Pathways
- Secretion
- Osteoblast Differentiation
- Limb Development
- Pathogenesis
- Osteoclast Differentiation
- Cell Cycle Checkpoint
- Cell Fate Determination
- Mammary Gland Development
- Sex Determination
- Limb Morphogenesis
- Cell Cycle
- Gonad Development
- Meiosis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rspo2
bosterbio.com/bosterbio-gene-info-cards/Rspo2
References
PMID: 15469841 by Kazanskaya O., et al. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.
PMID: 16543246 by Nam J.-S., et al. Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.