RRP1B Antibodies

AND RRP1B ELISA kits, RRP1B Proteins

Many biological assays use antibodies to detect RRP1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RRP1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RRP1B antibodies...

We validate the specificity of these antibodies to RRP1B by testing them on tissues known to express RRP1B positively and negatively. Browse below to find the RRP1B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RRP1B Infographic by Boster Bio

All RRP1B Products

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Price

RRP1B (NM_015056) Human Over-expression Lysate

Human

$628
Cat # LS023076
100 µg

Anti-RRP1B Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A08159-1
100 µg/vial

RRP1B Overview

Facts about Ribosomal RNA processing protein 1 homolog B.

RRP1B 3D structure. Source: alphafold

Ribosomal RNA processing protein 1 homolog B (RRP1B)

Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688).

Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity).

Gene Information

Human
Gene Name:	RRP1B
Uniprot:	Q14684
Entrez:	23076

Family

Belongs to:

RRP1 family

Alternative Names

Nnp1; ribosomal RNA processing 1 homolog B (S. cerevisiae); RRP1

Molecular Weight

Mass (kDA):
84.428 kDA

Genomic Context


Human

Location:	21q22.3
Sequence:	21; NC_000021.9 (43659560..43696079)

Subcellular Localizations

Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015).; Nucleus, nucleoplasm. (Microbial infection) Following infection by influenza A virus, partially translocates from the nucleolus to the nucleoplasm.

Diseases

Malignant Neoplasms
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Tumor Progression
Neoplasms
Mammary Neoplasms
Cell Transformation, Neoplastic
Down Syndrome

Carcinoma
Lymphatic Metastasis
Hyperplasia

Interacting Proteins

E2F1
FBL
HIST1H4A
PARP1
PPP1CA

PPP1CB
PPP1CC
RPL27
RPL5
RRP1

SRSF1

Pathways

Rna Processing
Ribosome Biogenesis
Induction Of Apoptosis
Cell Cycle
Localization
Rrna Processing

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RRP1B

References

PMID: 19710015 by Crawford N.P., et al. The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.

PMID: 20040599 by Paik J.C., et al. Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.