RPS6KA4 Antibodies

Ribosomal protein S6 kinase alpha-4 (RPS6KA4)

Serine/threonine-protein kinase that's required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, which contributes to gene activation by histone phosphorylation and works in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli like UV-C irradiation, epidermal growth factor (EGF) and anisomycin.

Plays an important role in the control of RELA transcriptional activity in response to TNF. Phosphorylates'Ser-10' of histone H3 in reaction to mitogenics, stress stimulation and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN.

Gene Information

Human
Gene Name:	RPS6KA4
Uniprot:	O75676
Entrez:	8986

Family

Belongs to:
protein kinase superfamily

Alternative Names

MSK2; ribosomal protein S6 kinase, 90kDa, polypeptide 4; RPS6KA4; RSKB

Molecular Weight

Mass (kDA):
85.606 kDA

Genomic Context

Human
Location:	11q13.1
Sequence:	11; NC_000011.10 (64359162..64372215)

Subcellular Localizations

Nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Psoriasis
• Physiological Stress
• Inflammation
• Carcinogenesis
• Contact Dermatitis
• Cholangiocarcinoma
• Neoplasm Metastasis
• Neoplasms, Second Primary
• Uterine Cervical Neoplasm
• Hypoxia
• Teratocarcinoma

• Mitochondrial Damage
• Malignant Tumor Of Cervix
• Dermatitis, Allergic Contact
• Carcinoma
• Uveomeningoencephalitic Syndrome
• Therapy-related Acute Myeloid Leukemia
• Therapy-related Leukemia

Interacting Proteins

• MAPK14

Pathways

• Cytokine Production
• Pathogenesis
• Response To Stress
• Chromatin Remodeling
• Protein Phosphorylation
• Response To Anisomycin
• Immune Response
• Cell Cycle Arrest
• Histone H3 Acetylation
• Translation
• Cell Cycle

• Cell Death
• Cell Growth
• Mapk Cascade
• Interphase
• Glycolysis

PTMs

• Phosphorylation

• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPS6KA4

Boster Bio - Best Uses Of The RPS6KA4 Marker

This article will discuss the primary antibodies from Steven Boster, one of the most respected names in the research community. We will also discuss the work He has done with BRAF and RPS6KA4.

His work with RPS6KA4

The discovery of protein serine/threonine kinase activity in RPS6KA4 is a key step in the understanding of signal transduction in intracellular systems. This enzyme has a predicted role in protein phosphorylation and intracellular signal transduction. In addition to its role in intracellular signal transduction, Boster also predicted that RPS6 kinase could also play an important role in the process of protein phosphorylation.

His work with BRAF

The discovery of the RPS6KA4 gene marker is the latest addition to the list of biomarkers. The gene is predicted to be involved in intracellular signal transduction and protein phosphorylation. The discovery of the RPS6KA4 gene is promising, as it could help doctors predict patient response to radiotherapy. However, the future of the marker depends on further research. In the meantime, it is an essential part of personalized medicine.