RPS6KA1 Antibodies

Ribosomal protein S6 kinase alpha-1 (RPS6KA1)

In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which leads to the following transcriptional activation of numerous immediate-early genes. Upon insulin- derived signal, acts indirectly on the transcription regulation of many genes by phosphorylating GSK3B at'Ser-9' and inhibiting its activity.

Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complicated. In response to insulin, phosphorylates EIF4B, improving EIF4B affinity for the EIF3 complicated and stimulating cap-dependent translation.

Gene Information

Human
Gene Name:	RPS6KA1
Uniprot:	Q15418
Entrez:	6195

Family

Belongs to:
protein kinase superfamily

Alternative Names

90kD, polypeptide 1); EC 2.7.11; EC 2.7.11.1,90 kDa ribosomal protein S6 kinase 1; HU-1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPL1A; p90RSK1; p90S6K; ribosomal protein S6 kinase alpha 1; ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; Ribosomal S6 kinase 1; RPS6KA1; RSK; RSK1; RSK-1; RSK1p90-RSK 1; S6K-alpha 1; S6K-alpha-1

Molecular Weight

Mass (kDA):
82.723 kDA

Genomic Context

Human
Location:	1p36.11
Sequence:	1; NC_000001.11 (26529761..26575028)

Subcellular Localizations

Nucleus. Cytoplasm.

Diseases

• Neoplasms
• Malignant Neoplasms
• Hypertrophy
• Insulin Resistance
• Obesity
• Inflammation
• Hyperplasia
• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Cell Transformation, Neoplastic
• Mammary Neoplasms
• Cardiac Hypertrophy
• Insulin Sensitivity

• Tuberous Sclerosis
• Sclerosis
• Yersinia Infections
• Atrophy
• Muscular Atrophy
• Polyps
• Leukemia, Myelocytic, Acute

Interacting Proteins

• AKAP8
• CDKN1B
• HSP90AB1
• MAPK1
• SCRIB

• VASP

Pathways

• Translation
• Cell Growth
• Pathogenesis
• Cell Proliferation
• Localization
• Cell Cycle
• Cell Death
• Autophagy
• Secretion
• Cell Motility
• Virulence
• Regeneration
• Neurogenesis

• Glucose Homeostasis
• Muscle Hypertrophy
• Glycolysis
• Transport
• Aging
• Glucose Transport
• Angiogenesis

PTMs

• Phosphorylation
• Cleavage
• Dephosphorylation

• Ubiquitination
• Glycosylation
• Acetylation

• Myristoylation

Research Areas

• MAP Kinase Signaling
• mTOR Pathway
• Phospho-Specific
• Protein Kinase
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPS6KA1

Boster Bio - Best Uses Of The RPS6KA1 Marker

In this article we'll explore the background of Steven Boster and His primary antibodies. This article will also provide information about Boster’s research and career. You'll learn why boster antibodies are the best on the market and why the research community respects their validity. After all, Boster antibodies are tested on Immunohistochemistry, Western Blotting, and ELISA as well.

His primary antibodies

His primary antibodies to this protein are highly specific. They also show reactivity for the RPS6KA1 markers. The His primary antibody was used to stain RPS6KA1 for a period of four hours at room temp. HIER used a Bond RX automatized platform to identify RPS6KA1's marker. The permeabilization stage was done with PF00011-C flowcytometry permbuffer.

His career

His involvement with the RPS6KA1 marker gene marker began when he noticed that AP2M1 was expressed in a similar manner to AP2M1. Both genes were involved regulating actin filament based processes as well RNA splicing. Both genes played important roles in proteasomal catabolism, as well the TOR signaling pathway. Moreover, they were both involved in transcription, which is one of the reasons they were identified together.

His research

His studies with the RPS6KA1 marker provided important information about this gene. RPS6KA1 plays a critical role in the regulation and catabolism of RNA splicing as well as actin filament-based processes. This gene also plays a critical role in TOR signals and proteasomal-protein catabolism. To better understand how RPS6KA1 and AP2M1 interact, the following information will be presented.