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60S ribosomal protein L5 Antibodies
AND RPL5 ELISA kits, 60S ribosomal protein L5 Proteins
Many biological assays use antibodies to detect 60S ribosomal protein L5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 60S ribosomal protein L5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 60S ribosomal protein L5 antibodies...
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RPL5 Overview
Facts about 60S ribosomal protein L5.
60S ribosomal protein L5 (RPL5)
The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs to a polypeptide chain.
The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains in the exit of the ribosomal tunnel. Included in the 5S RNP/5S ribonucleoprotein particle it is an essential part of the LSU, required for its creation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399).
Gene Information
| Human | |
|---|---|
| Gene Name: | RPL5 |
| Uniprot: | P46777 |
| Entrez: | 6125 |
Family
| Belongs to: |
|---|
| universal ribosomal protein uL18 family |
Alternative Names
DBA6,60S ribosomal protein L5; MGC117339; ribosomal protein L5
Molecular Weight
Mass (kDA):
34.363 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.1 |
| Sequence: | 1; NC_000001.11 (92831986..92841924) |
Subcellular Localizations
Cytoplasm. Nucleus, nucleolus.
Diseases
- Anemia
- Anemia, Diamond-blackfan
- Aplasia, Nos
- Malignant Neoplasms
- Congenital Abnormality
- Neoplasms
- Pancytopenia
- Growth Retardation
- Sclerosis
- Inherited Bone Marrow Failure Syndrome
- Pure Red-cell Aplasia
- Multiple Sclerosis
Interacting Proteins
- DCC
- Dcc
- MDM2
- RRP1B
Pathways
- Ribosome Biogenesis
- Translation
- Cell Death
- Pathogenesis
- Rrna Processing
- Transport
- Cell Cycle Arrest
- Cell Cycle
- Nuclear Import
- Rna Processing
- Organ Growth
- Rrna Transcription
- Cell Adhesion
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPL5
bosterbio.com/bosterbio-gene-info-cards/RPL5
References
PMID: 7772601 by Frigerio J.-M., et al. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.
PMID: 12962325 by Odintsova T.I., et al. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.