RPGRIP1 Antibodies

AND RPGRIP1 ELISA kits, RPGRIP1 Proteins

Many biological assays use antibodies to detect RPGRIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RPGRIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RPGRIP1 antibodies...

We validate the specificity of these antibodies to RPGRIP1 by testing them on tissues known to express RPGRIP1 positively and negatively. Browse below to find the RPGRIP1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RPGRIP1 Infographic by Boster Bio

All RPGRIP1 Products

Product

Figures

Specificity

Applications

Price

RPGRIP1 (NM_020366) Human Over-expression Lysate

Human

$960
Cat # LS057096
100 µg

RPGRIP1 Overview

Facts about X-linked retinitis pigmentosa GTPase regulator-interacting protein 1.

RPGRIP1 3D structure. Source: alphafold

X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1)

May be the scaffolding protein. Required for normal location of RPGR in the connecting cilium of photoreceptor cells.

Required for normal disk morphogenesis and disk organization from the outer segment of photoreceptor cells and for survival of photoreceptor cells. .

Gene Information

Human
Gene Name:	RPGRIP1
Uniprot:	Q96KN7
Entrez:	57096

Family

Belongs to:

RPGRIP1 family

Alternative Names

CORD13; DKFZp686P0897; LCA6RGRIP; retinitis pigmentosa GTPase regulator interacting protein 1; RGI1; RPGR-interacting protein 1; RPGRIP; RPGRIP1d; X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

Molecular Weight

Mass (kDA):
146.682 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (21287977..21351316)

Tissue Specificity

Strong expression in retina, with weaker expression in testis. Expressed in other neurons such as amacrine cells. Colocalizes with RGPR in the outer segment of rod photoreceptors and cone outer segments.

Subcellular Localizations

Cell projection, cilium. Situated between the axonemal microtubules and the plasma membrane (By similarity). In the retinal photoreceptor cell layer, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity). Colocalizes with RGPR in the photoreceptor connecting cilium (By similarity).

Diseases

Leber Congenital Amaurosis
Amaurosis
Retinitis Pigmentosa
Blind Vision
Dystrophy
Retinal Degeneration
Retinal Dystrophies
Optic Atrophy, Hereditary, Leber
Retinal Diseases
Atrophy
Nephronophthisis

Dog Diseases
Disorder Of Eye
Familial Aplasia Of The Vermis
Visual Impairment
Cystic Kidney Diseases
Cerebellar Diseases

Interacting Proteins

AEN
CBX8
CHCHD3
DPPA4
FAM74A4

FEM1C
GATAD2B
HEYL
MAGEB2
RPGR

RPP25L
SCNM1
TBC1D7
TRIB3
ZNF337

ZNF417
ZNF564

Pathways

Localization
Pathogenesis
Transport
Phototransduction
Proteolysis
Cell Death
Cell Cycle
Intraflagellar Transport
Metaphase
Translational Frameshifting
Decidualization

Cilium Assembly
Phagocytosis
Mating
Chromosome Condensation
Meiosis

PTMs

Cleavage

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPGRIP1

References

PMID: 10958648 by Roepman R., et al. The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.

PMID: 10958647 by Boylan J.P., et al. Identification of a novel protein interacting with RPGR.