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RPGRIP1 Antibodies
AND RPGRIP1 ELISA kits, RPGRIP1 Proteins
Many biological assays use antibodies to detect RPGRIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RPGRIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RPGRIP1 antibodies...
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RPGRIP1 Overview
Facts about X-linked retinitis pigmentosa GTPase regulator-interacting protein 1.
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1)
May be the scaffolding protein. Required for normal location of RPGR in the connecting cilium of photoreceptor cells.
Required for normal disk morphogenesis and disk organization from the outer segment of photoreceptor cells and for survival of photoreceptor cells. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RPGRIP1 |
| Uniprot: | Q96KN7 |
| Entrez: | 57096 |
Family
| Belongs to: |
|---|
| RPGRIP1 family |
Alternative Names
CORD13; DKFZp686P0897; LCA6RGRIP; retinitis pigmentosa GTPase regulator interacting protein 1; RGI1; RPGR-interacting protein 1; RPGRIP; RPGRIP1d; X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
Molecular Weight
Mass (kDA):
146.682 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (21287977..21351316) |
Tissue Specificity
Strong expression in retina, with weaker expression in testis. Expressed in other neurons such as amacrine cells. Colocalizes with RGPR in the outer segment of rod photoreceptors and cone outer segments.
Subcellular Localizations
Cell projection, cilium. Situated between the axonemal microtubules and the plasma membrane (By similarity). In the retinal photoreceptor cell layer, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity). Colocalizes with RGPR in the photoreceptor connecting cilium (By similarity).
Diseases
- Leber Congenital Amaurosis
- Amaurosis
- Retinitis Pigmentosa
- Blind Vision
- Dystrophy
- Retinal Degeneration
- Retinal Dystrophies
- Optic Atrophy, Hereditary, Leber
- Retinal Diseases
- Atrophy
- Nephronophthisis
Interacting Proteins
- AEN
- CBX8
- CHCHD3
- DPPA4
- FAM74A4
- FEM1C
- GATAD2B
- HEYL
- MAGEB2
- RPGR
Pathways
- Localization
- Pathogenesis
- Transport
- Phototransduction
- Proteolysis
- Cell Death
- Cell Cycle
- Intraflagellar Transport
- Metaphase
- Translational Frameshifting
- Decidualization
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPGRIP1
bosterbio.com/bosterbio-gene-info-cards/RPGRIP1
References
PMID: 10958648 by Roepman R., et al. The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
PMID: 10958647 by Boylan J.P., et al. Identification of a novel protein interacting with RPGR.