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- Table of Contents
5 Q&As
Facts about Protein XRP2.
Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Human | |
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Gene Name: | RP2 |
Uniprot: | O75695 |
Entrez: | 6102 |
Belongs to: |
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TBCC family |
DELXp11.3; KIAA0215; NME10; protein XRP2; retinitis pigmentosa 2 (X-linked recessive); TBCCD2; XRP2
Mass (kDA):
39.641 kDA
Human | |
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Location: | Xp11.3 |
Sequence: | X; NC_000023.11 (46837043..46882358) |
Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium. Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus.
If you're looking to use the RP2 Marker to study the causes of blindness, you've come to the right place. This article will review the RP2 Marker and its use in other types of blindness research. The limitations of the RP2 Marker are also discussed, as well as Steven Boster's background. If you're looking for more details, you can read about his background here.
RP2 is a protein that localizes to the sensory cilia. It interacts with a protein called polycystin-2, which is involved in renal ciliary disease. However, there are few well-defined uses for this gene. The present invention covers functional variants of proteins having substantial sequence identity or similarity to the parent protein, while maintaining biological activity. Various applications of RP2 are described below.
RP2 is a protein with multiple functions within cells. In particular, it is involved in the trafficking of NSF from the cilium to the synaptic region of photoreceptors. Interestingly, the RP2 Marker is expressed in a variety of tissues, including the retina. Therefore, the protein may also have potential to study other causes of blindness.
The team at Trinity College London and University College London have successfully immunolabeled RP2 in the human and rat retina. However, the immunoreactivity was very weak in the outer segment layer of the human and rodent retina. These findings highlight the importance of further studies to determine the right dose for treating patients with RP2 mutation. These researchers plan to use the RP2 Marker to study other causes of blindness.
The study suggests that the RP2 Marker may have additional applications. It has been shown that the protein can bind to the NSF of glial cells. This mechanism may also be applicable to other diseases, including cancer and diabetes. Because RP2 and NSF are co-localized, it is possible to identify other cellular mechanisms involved in blindness. The findings are promising and should help us understand other causes of blindness.
A full-length human RP2 was generated by PCR from a human retinal cDNA template. The antibodies were used to map the epitope of RP2 by co-immunoprecipitation. This method was further validated by immunoblotting with GST-RP2 fusion proteins. These experiments show that the monoclonal antibody is specific for RP2, a protein with an N-terminal amino acid sequence.
The RP2 Marker is a highly informative gene for carrier detection, early diagnosis, and disease characterization. However, because this gene is involved in multiple gene disorders, it is limited to families with a clear linkage to the RP locus. As a result, diagnostic services have been offered only to patients with known linkage to the RP locus. However, deeper analysis and novel mutations have revealed the identification of evolutionary conserved amino acid residues that may play crucial roles in RP2's function.
RP2 has been shown to localize to sensory cilia and interact with a ciliary GTPase called polycystin-2. Polycystin-2 has been implicated in renal ciliary disorders. Further studies will be needed to clarify how RP2 functions. Until then, this gene may remain a mystery. However, its limitations are not yet exhausted.
The background of Steven Boster is interesting, but what makes him unique? As a child, Steven has never gone to school, nor has he had his vitals taken. He is usually naive, ready for adventures, but his nature causes him to bite off more than he can chew. Luckily, the Homeworld Gems intervene and save him from himself. In his quest for fame, he encounters many unlikely allies, including the mysterious Crystal Gems.
As the son of two Gems, Steven has inherited the weaknesses of his human and Gem sides. His human half lacks the ability to self-restraint, and he is dependent on the gemstone to survive. When the White Diamond took away the gemstone from his body, Steven split into two entities: one Gem half and one human half. As the human half was weak, the Gem half sought to reconcile with the human half.
While his family values compromises over individuality, his strong love for his friends is a defining trait. He always makes an effort to help his friends, but will not resort to violence unless it is absolutely necessary. In addition to his innate willingness to help, Steven also has a good heart, which allows him to be a great friend to many. Despite his intense passion, however, his irrational nature can also be a hindrance to relationships.
Because of his difficult background, Steven struggles to process information. While he initially wanted to be like his mother, he wished he didn't know some of the things about her. He's also frustrated when Gems refuse to tell him the truth, and he feels compelled to get the truth about his mother. But despite the difficulties that he faces, he never gives up on his dreams.
Despite his deep desire to make amends with Connie, Steven's emotional vulnerability makes him vulnerable to manipulation. He assumes that his friends have moved on without him and that he's happy without them. As a result, he makes poor decisions and is easily manipulated. In the end, he ends up making mistakes in order to keep Connie happy. Although this may be a natural reaction to his character, it reflects the nature of his personality and the way in which he makes his decisions.
PMID: 9697692 by Schwahn U., et al. Positional cloning of the gene for X-linked retinitis pigmentosa 2.
PMID: 10942419 by Chapple J.P., et al. Mutations in the N-terminus of the X-linked retinitis pigmentosa protein RP2 interfere with the normal targeting of the protein to the plasma membrane.