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, No Gclids
Protein XRP2 Antibodies
AND RP2 ELISA kits, Protein XRP2 Proteins
Many biological assays use antibodies to detect Protein XRP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein XRP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein XRP2 antibodies...
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RP2 Infographic by Boster Bio
All RP2 Products
Product
Figures
Specificity
Applications
Price
Anti-RP2 Antibody Picoband®
5 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01923-1
100 μg/vial
Cat # A01923-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M01923
100 μg/vial
Cat # M01923
100 μg/vial
RP2 Overview
Facts about Protein XRP2.
Protein XRP2 (RP2)
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by causing hydrolysis of GTP ARL3, resulting in the launch of UNC119 (or UNC119B).
Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | RP2 |
| Uniprot: | O75695 |
| Entrez: | 6102 |
Family
| Belongs to: |
|---|
| TBCC family |
Alternative Names
DELXp11.3; KIAA0215; NME10; protein XRP2; retinitis pigmentosa 2 (X-linked recessive); TBCCD2; XRP2
Molecular Weight
Mass (kDA):
39.641 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.3 |
| Sequence: | X; NC_000023.11 (46837043..46882358) |
Tissue Specificity
Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).
Subcellular Localizations
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium. Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus.
Diseases
- Retinitis Pigmentosa
- Retinal Degeneration
- Blind Vision
- Genetic Diseases, X-linked
- Night Blindness
- Nervousness
- Retinal Diseases
- Dystrophy
- Myopia
- Malignant Neoplasms
- Atrophy
Interacting Proteins
- Arl3
Pathways
- Localization
- Neurogenesis
- Reflex
- Cell Division
- Segmentation
- Cell Death
- Axon Guidance
- Transport
- Cell Fate Specification
- Cell Cycle
- Secretion
- Axonogenesis
- Pyrethroid Resistance
PTMs
- Acylation
- Ribosylation
- Phosphorylation
- Myristoylation
Research Areas
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RP2
bosterbio.com/bosterbio-gene-info-cards/RP2
References
PMID: 9697692 by Schwahn U., et al. Positional cloning of the gene for X-linked retinitis pigmentosa 2.
PMID: 10942419 by Chapple J.P., et al. Mutations in the N-terminus of the X-linked retinitis pigmentosa protein RP2 interfere with the normal targeting of the protein to the plasma membrane.